Bacteriological study of Acne Vulgaris in Cairo Egypt
Bacteriological study of Acne Vulgaris in Cairo Egypt
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埃及开罗寻常痤疮的细菌学研究
DOI：
10.12816/ejhm.2018.10742
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Samah Hamdy Tawfik
中科院分区：
文献类型：
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作者：
Taimor Mohammed Khalifa El;M. Mohammed;Y. Hamed;Samah Hamdy Tawfik
背景资料：寻常痤疮是毛囊皮脂腺单位的慢性炎性皮肤病，其特征在于开放性和/或闭合性粉刺（黑头粉刺和白头粉刺）和炎性损伤，包括丘疹、脓疱或结节，在某些情况下伴有瘢痕形成。痤疮是一种多因素疾病，包括皮脂分泌增加、毛囊皮脂腺管角化过度、微生物植物群异常，特别是痤疮丙酸杆菌在毛囊皮脂腺管定植以及炎症的产生。痤疮丙酸杆菌与痤疮的发病机制有关已有100多年的历史。
目的：目前的工作是确定埃及痤疮患者中涉及寻常痤疮的细菌。
患者和方法：该研究对从Al-Hussien医院皮肤科门诊招募的100名患有炎性寻常痤疮的患者进行。
结果：表皮葡萄球菌在正常皮肤中的检出率高于痤疮皮损。而痤疮皮损中痤疮丙酸杆菌含量高于正常皮肤，差异有统计学意义。在有氧和无氧状态下，分离出的微生物类型与痤疮病变的严重程度之间存在显着关系。痤疮家族史阳性与痤疮后瘢痕形成有显著相关性。虽然痤疮皮损的严重程度与激素治疗无明显关系。我们注意到大多数有POP病史的女性患者有中度痤疮病变。在这项研究中，在有氧状态下的中度痤疮病变和正常皮肤中观察到高百分比的表皮葡萄球菌，但在有氧状态下的中度痤疮病变中发现高百分比的痤疮丙酸杆菌。然而，痤疮丙酸杆菌不能单独负责发炎痤疮病变中炎症的起始或其严重程度的变化。
结论：在这项研究中，高百分比的无生长结果提示我们抗生素治疗不是痤疮的最有效治疗，并且存在其他有效的治疗方法，无论是局部的如retenoids还是消融的如激光。有痤疮病变家族史的患者，特别是第一亲属（母亲），我们必须记住，他们更容易患上痤疮后疤痕，所以我们应该尽早开始完美的治疗，以防止痤疮后后遗症。
Background: acne vulgaris is chronic inflammatory dermatosis of the pilosebaceous units which is characterized by open and/or closed comedones (blackheads and whiteheads) and inflammatory lesions including papules, pustules, or nodules, in some cases, is accompanied by scarring. Acne is multifactorial disease including increased sebum production, hypercornification of pilosebaceous duct, an abnormality of microbial flora especially colonization of the duct with propionibacterium acne and the production of inflammation. P.acne has been implicated in the pathogenesis of acne for more than 100 years.
Objective: the present work was done to determine bacteria involved in acne vulgaris among Egyptian acne patients.
Patients and Methods: this study was conducted on one hundred patients with inflammatory acne vulgaris recruited from the Dermatology outpatient clinic of Al-Hussien hospital.
Results: in this study, S.epidermidis was higher in normal skin than in acne lesion. But P.acne was higher in acne lesion than in normal skin with significant statistical difference. There was a significant relation between type of organisms isolated and severity of acne lesions in both aerobic and anaerobic state. There was a significant relation between positive acne family history and liability for post acne scar. Even though there was no significant relation between hermonal therapy and severity of acne lesions. We noticed that the majority of female patients with POP history had moderate acne lesions. In this study, the high percentage of S.epidermidis was observed in moderate acne lesion and in normal skin in aeorobic state but high percentage of P.acne was found in moderate acne lesions in anaerobic state. However, P.acne can not be solely held responsible for the initiation of inflammation in inflamed acne lesions or for the variation in its severity.
Conclusion: the high percentage of no growth result in this study directs us that the antibiotic treatments are not the most useful treatment for acne and there are other effective methods for treatment whether topical as retenoids or ablative as Lasers. Patient with family history of acne lesion especially first relative (mother) we must keep in mind that they are more susceptible for post acne scar so we should start with the perfect treatment as early as possible to prevent the post acne sequels.