The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies
The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies
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DOI：
10.1017/s0033291719000369
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发表时间：
2020-03-01
影响因子：
6.9
通讯作者：
Xiang, Yu-Tao
中科院分区：
文献类型：
--
作者：
Li, Xiao-Hong;Zhong, Xiao-Mei;Xiang, Yu-Tao
背景氯氮平治疗增加粒细胞缺乏症的风险，但粒细胞缺乏症的流行病学研究结果并不一致。本荟萃分析探讨了流行的粒细胞缺乏症和相关的死亡氯氮平治疗patients.MethodsA文献检索在国际（PubMed，PsycINFO，EMBASE）和中国（万方，中国国家知识基础设施，Sinomed）数据库进行。粒细胞缺乏症和氯氮平治疗患者相关死亡的患病率估计与综合荟萃分析程序使用的随机效应model. ResultsThirteen 1984年和2018年之间发表的260 948例氯氮平治疗患者的研究被纳入荟萃分析。粒细胞缺乏症和粒细胞缺乏症导致的死亡的总体患病率分别为0.4%（95% CI 0.3-0.6%）和0.05%（95% CI 0.03-0.09%）。粒细胞缺乏症的患病率是温和的样本量，研究质量，年的出版物，和数据collection.ConclusionsThe氯氮平相关的粒细胞缺乏症的患病率是低的。粒细胞缺乏症相关死亡似乎罕见。
BackgroundClozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients.MethodsA literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Prevalence estimates of agranulocytosis and related death in clozapine-treated patients were synthesized with the Comprehensive Meta-Analysis program using the random-effects model.ResultsThirty-six studies with 260 948 clozapine-treated patients published between 1984 and 2018 were included in the meta-analysis. The overall prevalence of agranulocytosis and death caused by agranulocytosis were 0.4% (95% CI 0.3-0.6%) and 0.05% (95% CI 0.03-0.09%), respectively. The prevalence of agranulocytosis was moderated by sample size, study quality, year of publication, and that of data collection.ConclusionsThe prevalence of clozapine-associated agranulocytosis is low. Agranulocytosis-related death appears rare.