MicroRNAs and Cardiovascular Disease in Diabetes Mellitus.
MicroRNAs and Cardiovascular Disease in Diabetes Mellitus.
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MicroRNA 与糖尿病中的心血管疾病
DOI：
10.1155/2017/4080364
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发表时间：
2017
影响因子：
--
通讯作者：
Shan PF
中科院分区：
文献类型：
--
作者：
Ding Y;Sun X;Shan PF
心血管疾病是糖尿病的主要大血管并发症。近年来，尽管由于对CVD危险因素的全面控制，CVD发病率和死亡率有所下降，但CVD仍然是许多国家糖尿病患者死亡的主要原因，这表明了潜在的潜在病理生理机制。MicroRNA是一类非编码的单链RNA分子，其参与β细胞功能、胰岛素分泌、胰岛素抵抗、骨骼肌和脂肪组织，并且在葡萄糖稳态和糖尿病并发症的发病机制中起重要作用。本文就microRNA在糖尿病内皮细胞和血管平滑肌细胞功能障碍、巨噬细胞和血小板活化、脂质代谢异常、心肌细胞复极化等方面的研究进展作一综述。本文还综述了microRNA作为糖尿病患者心血管疾病潜在生物标志物和治疗靶点的研究进展。
Cardiovascular disease (CVD) is the major macrovascular complication of diabetes mellitus. Recently, although CVD morbidity and mortality have decreased as a result of comprehensive control of CVD risk factors, CVD remains the leading cause of death of patients with diabetes in many countries, indicating the potential underlying pathophysiological mechanisms. MicroRNAs are a class of noncoding, single-stranded RNA molecules that are involved in β-cell function, insulin secretion, insulin resistance, skeletal muscle, and adipose tissue and which play an important role in glucose homeostasis and the pathogenesis of diabetic complications. Here, we review recent progress in research on microRNAs in endothelial cell and vascular smooth muscle cell dysfunction, macrophage and platelet activation, lipid metabolism abnormality, and cardiomyocyte repolarization in diabetes mellitus. We also review the progress of microRNAs as potential biomarkers and therapeutic targets of CVD in patients with diabetes.