Amino acid metabolism in liver disease.
Amino acid metabolism in liver disease.
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DOI：
10.1097/00075197-199901000-00009
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发表时间：
1999-01-01
影响因子：
3.1
通讯作者：
Grips, E
中科院分区：
文献类型：
--
作者：
Holm, E;Sedlaczek, O;Grips, E
肝衰竭时甲硫氨酸降解过程中硫转移的损害可以通过S-腺苷甲硫氨酸治疗来抵消。关于肝性脑病的发病机制，没有令人信服的证据存在色氨酸，谷氨酰胺或谷氨酸参与。门体分流引起的高氨血症可能降低血浆支链氨基酸。在肝硬化中葡萄糖对尿素合成的影响不存在。
The impairment of transsulphuration during methionine degradation in hepatic failure can be counteracted by treatment with S-adenosylmethionine. Regarding the pathogenesis of hepatic encephalopathy, no convincing evidence exists for tryptophan, glutamine or glutamate being involved. Portal-systemic shunting-induced hyperammonaemia may reduce plasma branched-chain amino acids. The glucose effect on urea synthesis does not exist in cirrhosis.