Mutation and epigenetic molecular clocks in cancer.
Mutation and epigenetic molecular clocks in cancer.
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DOI：
10.1093/carcin/bgq239
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发表时间：
2011-02
期刊：
影响因子：
4.7
通讯作者：
D. Shibata
中科院分区：
文献类型：
--
作者：
D. Shibata
进化的一个难题是如何衡量随时间的变化。一种自然的倾向是使用形态学标准——两种表型之间的差异越大，进化这些差异所需的时间就越长。然而，表象可能具有欺骗性，推断时间的另一种方法是使用分子钟。在这里，两个基因组之间的差异越大，平均而言，自共同祖先以来的时间就越长。 DNA 测序的最新进展为人类癌症的演变提供了新的线索。
A quandary of evolution is how to measure change over time. A natural inclination is to use morphologic criteria-the greater the differences between two phenotypes, the greater amount of time needed to evolve these differences. However, appearances may be deceiving, and another approach to infer time is with molecular clocks. Here, the greater the differences between two genomes, on average the greater the time since a common ancestor. Recent advances in DNA sequencing shed new light on how human cancers might evolve.