S100 family signaling network and related proteins in pancreatic cancer (Review)
S100 family signaling network and related proteins in pancreatic cancer (Review)
复制标题
DOI：
10.3892/ijmm.2014.1633
复制
发表时间：
2014-04-01
影响因子：
5.4
通讯作者：
Xiao, Ming-Bing
中科院分区：
文献类型：
--
作者：
Ji, Yi-Fei;Huang, Hua;Xiao, Ming-Bing
胰腺癌的发生发展是一个多病因、多分期、多因素交织的复杂过程。S100蛋白是S100家族的成员，调节与胰腺癌进展和转移相关的多种细胞通路。S100蛋白具有广泛的细胞内和细胞外功能，包括调节蛋白质磷酸化和酶活性，钙稳态以及调节细胞骨架成分和转录因子。S100蛋白与晚期糖基化终产物受体（RAGE）、p53和p21相互作用，在细胞外基质（ECM）的降解和转移中发挥作用，并在胰腺癌的进展和转移中与细胞骨架蛋白和质膜相互作用。S100A11和S100P是胰腺癌的重要肿瘤标志物，但对手术切除患者的预后不利。最近，S100A2被认为是胰腺癌的阴性预后生物标志物，S100A6的表达可能是一个独立的预后影响因素。S100A4和S100P的表达与耐药、分化、转移及临床结局相关。现就S100家族信号网络及其相关蛋白在胰腺癌中的作用及意义作一综述。
The occurrence and development of pancreatic cancer is a complex process convoluted by multi-pathogenies, multi-stages and multi-factors. S100 proteins are members of the S100 family that regulate multiple cellular pathways related to pancreatic cancer progression and metastasis. S100 proteins have a broad range of intracellular and extracellular functions, including the regulation of protein phosphorylation and enzyme activity, calcium homeostasis and the regulation of cytoskeletal components and transcriptional factors. S100 proteins interact with receptor for advanced glycation end-products (RAGE), p53 and p21, which play a role in the degradation of the extracellular matrix (ECM) and metastasis, and also interact with cytoskeletal proteins and the plasma membrane in pancreatic cancer progression and metastasis. S100A11 and S100P are significant tumor markers for pancreatic cancer and unfavorable predictors for the prognosis of patients who have undergone surgical resection. Recently, S100A2 has been suggested to be a negative prognostic biomarker in pancreatic cancer, and the expression of S100A6 may be an independent prognostic impact factor. The expression of S100A4 and S100P is associated with drug resistance, differentiation, metastasis and clinical outcome. This review summarizes the role and significance of the S100 family signaling network and related proteins in pancreatic cancer.