Calcium signalling in growth cone migration
Calcium signalling in growth cone migration
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DOI：
10.1016/j.ceca.2005.01.007
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发表时间：
2005-05-01
期刊：
影响因子：
4
通讯作者：
Bolsover, SR
中科院分区：
文献类型：
--
作者：
Bolsover, SR
生长锥是位于轴突和树突顶端的能动结构，它对各种各样的信号做出反应，要么转向信号，要么远离信号。胞浆钙信号似乎介导了这两种类型的反应的大部分。钙信号可以通过质膜通道的流入或通过从细胞内储存释放而产生。虽然神经递质可以通过离子型受体引起钙内流，但其他化学线索通过膜电压变化以外的机制打开质膜电压门控钙通道。一般来说，有吸引力的线索产生空间和时间限制的钙增加，难以检测使用传统的指标。这些钙信号的一个靶点是钙调蛋白依赖性蛋白激酶II。排斥性线索产生空间和时间上更扩散的钙增加，可以更容易地检测到使用荧光指示剂。这些的一个靶点是磷酸酶钙调磷酸酶，其可以通过使GAP 43去磷酸化并允许后者覆盖肌动蛋白丝来起作用。(c)2005爱思唯尔有限公司保留所有权利。
Growth cones, the motile structures at the tips of advancing axons and dendrites, respond to a wide range of cues by either turning towards or away from the cue. Cytosolic calcium signals appear to mediate a large fraction of both types of response. Calcium signals can be generated by influx through plasma membrane channels or by release from intracellular stores. While neurotransmitters can elicit calcium influx through ionotropic receptors, other chemical cues open plasma membrane voltage gated calcium channels by a mechanism other than a change of membrane voltage. In general attractive cues generate spatially and temporally restricted calcium increases that are difficult to detect using conventional indicators. One target for these calcium signals is calmodulin dependent protein kinase II. Repulsive cues generate spatially and temporally more diffuse calcium increases that can be more readily detected using fluorescent indicators. One target for these is the phosphatase calcineurin, which may act by dephosphorylating GAP43 and allowing the latter to cap actin filaments. (c) 2005 Elsevier Ltd. All rights reserved.