Predicting developmental outcomes in preterm infants A simple white matter injury imaging rule
Predicting developmental outcomes in preterm infants A simple white matter injury imaging rule
复制标题
DOI：
10.1212/wnl.0000000000008172
复制
发表时间：
2019-09-24
期刊：
影响因子：
9.9
通讯作者：
Miller, Steven P.
中科院分区：
文献类型：
--
作者：
Cayam-Rand, Dalit;Guo, Ting;Miller, Steven P.
目的根据脑白质损伤(WMI)的病变部位，建立一种预测早产儿4.5年神经发育结局的简单成像规则，并检验临床变量是否能提高预测能力。60名新生儿的45年结果的3DT1加权图像被重新格式化并与后连合眼平面对齐，WMI根据位置进行分类：仅在重新格式化的轴向平面上位于脑室中线的前面或后面。4.5年的不良结局定义为韦氏学龄前和小学智商
ObjectiveTo develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction.MethodsSixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7 weeks) were diagnosed with WMI on early brain MRI scans (median 32.3 weeks). 3D T1-weighted images of 60 neonates with 4.5-year outcomes were reformatted and aligned to the posterior commissure-eye plane and WMI was classified by location: anterior or posterior-only to the midventricle line on the reformatted axial plane. Adverse outcomes at 4.5 years were defined as Wechsler Preschool and Primary Scale of Intelligence full-scale IQ