Application of Microflow Conditions to Visible Light Photoredox Catalysis
Application of Microflow Conditions to Visible Light Photoredox Catalysis
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DOI：
10.1021/ol3005529
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发表时间：
2012-06-01
期刊：
影响因子：
5.2
通讯作者：
Zeitler, Kirsten
中科院分区：
文献类型：
--
作者：
Neumann, Matthias;Zeitler, Kirsten
微流动条件在可见光氧化还原催化中的应用已被成功地开发出来。操作简单的微型反应器和FEP(氟化乙丙共聚物)管式反应器系统可以显著改善使用不同光催化剂如[Ru(Bpy)(3)](2+)和曙红Y的几种光氧化还原反应。除了速度加快外，这种方法还促进了以前具有挑战性的非稳定中间体的转化。此外，醛的协同催化对映体选择性光氧化还原α-烷基化反应的产率被证明提高了2个数量级。
Applications of microflow conditions for visible light photoredox catalysis have successfully been developed. Operationally simple microreactor and FEP (fluorinated ethylene propylene copolymer) tube reactor systems enable significant improvement of several photoredox reactions using different photocatalysts such as [Ru(bpy)(3)](2+) and Eosin Y. Apart from rate acceleration, this approach facilitates previously challenging transformations of nonstabilized intermediates. Additionally, the productivity of the synergistic, catalytic enantioselective photoredox alpha-alkylation of aldehydes was demonstrated to be increased by 2 orders of magnitude.