Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study
Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study
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DOI：
10.2337/dc07-1117
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发表时间：
2008-04-01
期刊：
影响因子：
16.2
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Ilanne-Parikka, Pirjo;Eriksson, Johan G.;Tuomilehto, Jaakko
目的-芬兰糖尿病预防研究的二次分析的目的是评估生活方式干预对代谢综合征及其组成部分的影响。研究设计和方法-共有522名中年超重男性和女性葡萄糖耐量受损被随机分为个性化的生活方式干预组或标准护理对照组。国家胆固醇教育计划标准用于定义代谢综合征。结果-在研究结束时，平均随访3.9年，我们发现，与对照组相比，干预组的代谢综合征患病率显著降低（优势比[OR] 0.62 [95%CI 0.40-0.95]）和腹部肥胖的患病率（0.48 [0.28-0.81]）。结论-结果表明，从长远来看，生活方式干预也可能降低心血管疾病的风险。
OBJECTIVE - The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components.RESEARCH DESIGN AND METHODS - A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome.RESULTS - At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40-0.95]) and in the prevalence of abdominal obesity (0.48 [0.28-0.81]).CONCLUSIONS - The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.