Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.
Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.
复制标题
飞行精准医学：利用果蝇破译帕金森病的基因与环境相互作用。
DOI：
10.1093/toxsci/kfab060
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Feany,MelB
中科院分区：
文献类型：
--
作者：
Sarkar,Souvarish;Feany,MelB
Big data approaches have profoundly influenced state-of-the-art in many fields of research, with toxicology being no exception. Here, we use Parkinson’s disease as a window through which to explore the challenges of a dual explosion of metabolomic data addressing the myriad environmental exposures individuals experience and genetic analyses implicating many different loci as risk factors for disease. We argue that new experimental approaches are needed to convert the growing body of omics data into molecular mechanisms of disease that can be therapeutically targeted in specific patients. We outline one attractive strategy, which capitalizes on the rapid generation time and advanced molecular tools available in the fruit fly,Drosophila, to provide a platform for mechanistic dissection and drug discovery.
