Mobile genetic elements: in silico, in vitro, in vivo.
Mobile genetic elements: in silico, in vitro, in vivo.
复制标题
移动遗传元件：计算机、体外、体内。
DOI：
10.1111/mec.13543
复制
发表时间：
2016
影响因子：
4.9
通讯作者：
Rice,PhoebeA
中科院分区：
文献类型：
--
作者：
Arkhipova,IrinaR;Rice,PhoebeA
移动的遗传元件（MGEs），又称转座元件（TEs），是基因组中普遍存在的遗传元件，与基因组的组织、功能和进化密切相关。然而，目前存在的差距之间的快速TE发现在硅片，由指数增长的比较基因组研究，和有限数量的实验模型服从于更传统的体外和体内研究的结构，机械和监管性质的不同MGE。最近在位于美国马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）举行的一次会议上，实验和计算科学家齐聚一堂，弥合这一差距，会议名为“移动的遗传元件：计算机模拟、体外、体内”。
Mobile genetic elements (MGEs), also called transposable elements (TEs), represent universal components of most genomes and are intimately involved in nearly all aspects of genome organization, function and evolution. However, there is currently a gap between the fast pace of TE discovery in silico,driven by the exponential growth of comparative genomic studies, and a limited number of experimental models amenable to more traditional in vitro and in vivo studies of structural, mechanistic and regulatory properties of diverse MGEs. Experimental and computational scientists came together to bridge this gap at a recent conference, ‘Mobile Genetic Elements: in silico,in vitro, in vivo’, held at the Marine Biological Laboratory (MBL) in Woods Hole, MA, USA.