Protection against Cancer with Medicinal Herbs via Activation of Tumor Suppressor.
Protection against Cancer with Medicinal Herbs via Activation of Tumor Suppressor.
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DOI：
10.1155/2012/236530
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发表时间：
2012
影响因子：
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通讯作者：
Matsuda S
中科院分区：
文献类型：
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作者：
Kitagishi Y;Kobayashi M;Matsuda S
癌症仍然是死亡的主要原因，尽管正在研究开发更有效的药物。一些草药已显示出预防癌症和其他慢性疾病的发生和/或进展的潜力。正在对它们进行全面筛选，以探索开发可行抗癌药物的可能性。然而，需要更多的信息，对特定草药的反应和分子靶点。似乎有些草药和肿瘤抑制分子之间有关系，这些分子可以保护细胞免受癌症的侵害。本文综述了近年来中草药的研究进展，重点介绍了中草药的抗癌作用及其分子机制，为中草药的进一步研究提供参考。
Cancer remains a major cause of death, although research is ongoing for the development of more effective drugs. Some herbs have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases. They are being screened comprehensively to explore the possibility of development of feasible anticancer drugs. However, more information is required about the response to and the molecular target for specific herbs. It seems that there is a relationship between some medicinal herbs and tumor suppressor molecules which protect a cell from cancer. In this paper, we summarize the progress of recent research on herbs, with a particular focus on its anticancer role and molecular mechanisms underlying the cancer prevention property, supporting design for further research in this field.