Cigarette smoking and bladder cancer risk: an evaluation based on a systematic review of epidemiologic evidence in the Japanese population
Cigarette smoking and bladder cancer risk: an evaluation based on a systematic review of epidemiologic evidence in the Japanese population
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DOI：
10.1093/jjco/hyv188
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发表时间：
2016-03-01
影响因子：
2.4
通讯作者：
Sasazuki, Shizuka
中科院分区：
文献类型：
--
作者：
Masaoka, Hiroyuki;Matsuo, Keitaro;Sasazuki, Shizuka
尽管多项流行病学研究表明吸烟是膀胱癌的重要危险因素，但尚未对日本人群进行系统评价。准确评估日本人群与吸烟相关的膀胱癌风险可以为日本政策制定者和医生提供必要的信息，以启发戒烟的重要性。我们回顾了流行病学数据，以估计日本人群中吸烟与膀胱癌之间关联的强度。我们确定了之前的队列研究和病例对照研究，从 MEDLINE (PubMed) 和 Ichushi 的数据库中提取数据。每项研究均评估了关联程度和证据强度，并进行荟萃分析以获得总体关联程度的汇总估计。确定了三项队列研究和八项病例对照研究。除一项病例对照研究外，所有研究均表明吸烟与膀胱癌之间存在很强的正相关性。在固定效应模型中，曾经吸烟者相对于从不吸烟者的总体相对风险为 2.14（95% 置信区间 1.87-2.44）。我们得出结论，吸烟是日本人膀胱癌的一个令人信服的危险因素。
Although several epidemiological studies have demonstrated that cigarette smoking is an important risk factor for bladder cancer, no systematic review in the Japanese population has yet been performed. Accurate evaluation of bladder cancer risk in relation to smoking for Japanese populations can provide necessary information for Japanese policy-makers and doctors to enlighten the importance of smoking cessation. We reviewed epidemiologic data to estimate the strength of the association between cigarette smoking and bladder cancer in the Japanese population.We identified previous cohort and case-control studies, extracting data from databases in the MEDLINE (PubMed) and Ichushi. The magnitude of association and strength of evidence were evaluated in each study, and a meta-analysis was conducted to obtain summary estimates for the overall magnitude of association.Three cohort and eight case-control studies were identified. Except for one case-control study, all studies showed a strong positive association between cigarette smoking and bladder cancer. The summary relative risk for ever smokers relative to never smokers was 2.14 (95% confidence interval 1.87-2.44) in a fixed-effect model.We conclude that cigarette smoking is a convincing risk factor for bladder cancer among Japanese.