Assessment of meibomian gland morphology by noncontact infrared meibography in Shih Tzu dogs with or without keratoconjunctivitis sicca
Assessment of meibomian gland morphology by noncontact infrared meibography in Shih Tzu dogs with or without keratoconjunctivitis sicca
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DOI：
10.1111/vop.12645
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发表时间：
2019-11-01
影响因子：
1.6
通讯作者：
Saito, Akihiko
中科院分区：
文献类型：
--
作者：
Kitamura, Yasunari;Maehara, Seiya;Saito, Akihiko
目的应用非接触式红外线睑板成像技术观察干燥性角结膜炎（KCS）犬睑板腺（MG）的形态学变化。2011年至2017年，12只西施犬（平均年龄10.7岁，范围7-13岁）的14只眼睛被送到八云动物医院或三角动物眼科诊所，其临床体征和Schirmer撕裂试验（STT）结果与KCS（15 mm/min）一致，作为健康对照。两组犬均接受常规裂隙灯生物显微镜检查，然后使用台式和移动式系统对上眼睑进行非接触式红外线睑板造影。视网膜造影显示11只KCS犬13只眼MG形态异常。KCS组14眼中腺体缩短占64%，腺体脱落占64%。对照组10只犬16只眼MG形态学改变。对照组28眼中，46%的眼缩短，17.8%的眼脱落。KCS眼的脱落率明显高于对照眼（P 0.01）。与对照组动物相比，KCS组西施犬MG异常的频率增加。与泪液蒸发增加和保留减少相关的泪膜质量降低可能会加剧水缺乏动物泪液体积减少的影响。结论
Objective To investigate meibomian gland (MG) morphology by noncontact infrared meibography in Shih Tzu dogs with or without keratoconjunctivitis sicca (KCS). Procedures Fourteen eyes of 12 Shih Tzu dogs (mean age of 10.7 years, range of 7-13 years) presented to Yakumo Animal Hospital or Triangle Animal Eye Clinic from 2011 to 2017 with clinical signs and a Schirmer tear test (STT) result consistent with KCS ( 15 mm/min served as healthy controls. Both groups of dogs underwent routine slitlamp biomicroscopy followed by noncontact infrared meibography of the upper eyelid with both desktop-type and mobile-type systems. Meibography revealed morphological abnormalities of MGs in 13 eyes of 11 dogs with KCS. The abnormalities included gland shortening in 64% and gland dropout in 64% of the 14 eyes in the KCS group. Morphological changes were also observed in MGs of 16 eyes of 10 dogs in the control group. These changes included shortening in 46% and dropout in 17.8% of the 28 eyes in the control group. Dropout was significantly more common in eyes with KCS than in control eyes (P 0.01). The frequency of MG abnormalities is increased in Shih Tzus with KCS compared with control animals. A reduced quality of the tear film associated with increased evaporation and reduced retention of tear fluid likely exacerbates the effects of a reduced tear volume in animals with aqueous deficiency. ResultsConclusions