A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5.
A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5.
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DOI：
10.1007/s12035-016-9792-7
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发表时间：
2017-04
影响因子：
5.1
通讯作者：
Lahiri, Debomoy K.
中科院分区：
文献类型：
--
作者：
Shah, Kavita;Lahiri, Debomoy K.
cdk 5是细胞周期蛋白依赖性激酶家族成员，是神经元细胞骨架动力学的全局协调者。在胚胎发育过程中，Cdk 5是大脑发育不可或缺的。在成年人中，它对许多神经元过程至关重要，包括更高的认知功能，如学习和记忆形成，药物成瘾，疼痛信号和长期行为变化，通过长期增强和长期抑制，所有这些都依赖于细胞骨架的快速改变。Cdk 5活性在各种脑疾病中变得失调，包括阿尔茨海默病、帕金森病、亨廷顿病、注意力缺陷多动障碍、癫痫、精神分裂症和缺血性中风;这些都导致神经元细胞骨架的深刻重塑。这篇评论特别关注Cdk 5在调节神经元微管重塑中的多效性贡献。由于绝大多数Cdk 5的生理底物与神经元细胞骨架相关，我们的重点是Cdk 5底物，如CRMP 2，stathmin，drexine，dixdc 1，轴蛋白，GKAP，驱动蛋白-5，tau和PSD-95，这使得解开的分子机制，Cdk 5发挥其不同的作用，在调节神经元微管动力学，无论是在健康和疾病状态。
Cdk5, a cyclin dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling and long term behavior changes through long term potentiation and long term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, attention-deficit hyperactivity disorder, epilepsy, schizophrenia and ischemic stroke; these all result in profound remodeling of the neuronal cytoskeleton. This Commentary specifically focuses on the pleiotropic contribution of Cdk5 in regulating neuronal microtubule remodeling. Because the vast majority of the physiological substrates of Cdk5 are associated with the neuronal cytoskeleton, our emphasis is on the Cdk5 substrates, such as CRMP2, stathmin, drebrin, dixdc1, axin, GKAP, kinesin-5, tau and PSD-95, that have allowed to unravel the molecular mechanisms through which Cdk5 exerts its divergent roles in regulating neuronal microtubule dynamics, both in healthy and disease states.
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影响因子：
10.6
作者：
Drerup, Justin M.;Hayashi, Kanehiro;Cui, Huxing;Mettlach, Gabriel L.;Long, Michael A.;Marvin, Marian;Sun, Xiankai;Goldberg, Matthew S.;Lutter, Michael;Bibb, James A.
通讯作者：
Bibb, James A.
影响因子：
3
作者：
Benitez-King, G.;Ramirez-Rodriguez, G.;Meza, I
通讯作者：
Meza, I
影响因子：
9.2
作者：
Connell-Crowley, L;Le Gall, M;Giniger, E
通讯作者：
Giniger, E
影响因子：
4
作者：
Chang, Kuei-Hua;Vincent, Fabien;Shah, Kavita
通讯作者：
Shah, Kavita
影响因子：
16.2
作者：
Fischer, A;Sananbenesi, F;Tsai, LH
通讯作者：
Tsai, LH