Effects of Experimental Occlusal Interference on Dopamine Release in Rat Prefrontal Cortex.
Effects of Experimental Occlusal Interference on Dopamine Release in Rat Prefrontal Cortex.
复制标题
实验性咬合干扰对大鼠前额皮质多巴胺释放的影响。
DOI：
10.2186/jjps.44.284
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Hirofumi Yoshikawa
中科院分区：
文献类型：
--
作者：
Hirofumi Yoshikawa
研究咬合功能障碍后的咀嚼障碍是否对精神压力有影响是一个非常有趣的问题。因此，我们采用实验性咬合干扰，观察其对大鼠前额皮质多巴胺释放的影响。采用脑微透析法测定前额叶皮层胞外液多巴胺量。非功能期的实验性咬合干扰虽为口腔内干扰，但其影响不大。结果发现，前额皮质多巴胺的代谢没有变化。功能期的实验性咬合干扰，即在咬合干扰下的立方体食物喂养期，使前额皮质多巴胺量增加。实验结果表明，实验性咬合干扰通过改变大鼠前额叶皮层多巴胺的代谢而强烈影响大鼠的影响。立方体食物和粉状食物以同样的方式增加前额皮质多巴胺量。研究发现，食物质地的不同对前额皮质多巴胺量增加的过渡没有影响。与摄食行为相关的实验性咬合干扰影响了大鼠前额叶皮层多巴胺代谢，明确了实验性咬合干扰诱导了强烈的应激反应。
It is very interesting to determine whether disturbance of mastication following occlusal dysfunction has an effect on mental stress. Therefore, an experimental occlusal interference was attached, and the effect on dopamine release from the rat prefrontal cortex was examined.The extracellular fluid dopamine volume of the prefrontal cortex was measured by the brain microdialysis method.1. Though experimental occlusal interference during nonfunctional periods was intraoral, it. was found that the metabolism of the prefrontal cortex dopamine did not change.2. Experimental occlusal interference during functional periods, that is, feeding periods with cubed food under occlusal interference increased the prefrontal cortex dopamine volume. It was clarified that experimental occlusal interference strongly impacts the affect of the rat by changing the metabolism of dopamine in the prefrontal cortex.3. Cubed food and powdered food increased the prefrontal cortex dopamine volume in the same way. It was found that there was no difference in transition of the increase in the prefrontal cortex dopamine volume from the difference in the texture of the food.Experimental occlusal interference related to feeding behavior affected dopamine metabolism in the rat prefrontal cortex, and it was clarified that a strong stress reaction was induced by experimental occlusal interference.
影响因子：
15.9
作者：
M. Rizzo
通讯作者：
M. Rizzo