Adhesion of poly(vinyl alcohol) hydrogels by the electrophoretic manipulation of phenylboronic acid copolymers
Adhesion of poly(vinyl alcohol) hydrogels by the electrophoretic manipulation of phenylboronic acid copolymers
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DOI：
10.1039/c5tb00569h
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发表时间：
2015-01-01
影响因子：
7
通讯作者：
Kikuchi, Akihiko
中科院分区：
文献类型：
--
作者：
Asoh, Taka-Aki;Takaishi, Kohtaroh;Kikuchi, Akihiko
为了开发具有生物相容性和无毒特性的3D软材料，在这项研究中，我们试图通过使用电场和水溶性中间体苯基硼酸共聚物来快速粘附聚乙烯醇（PVA）水凝胶。聚（3-甲基丙烯酰胺基苯基硼酸-co-N，N-二甲基丙烯酰胺）共聚物在PVA水凝胶的界面处电泳操作后，PVA水凝胶彼此粘附。粘附的PVA界面在生理条件下是稳定的，但在过量的糖和酸的存在下观察到分离。分离的凝胶在相同条件下重新粘附，表明水凝胶的粘附具有可重复性。PVA和相关水凝胶的电泳粘附可用于组织工程领域，用于开发按需3D支架。
With the aim of developing 3D soft materials with biocompatibility and non-toxicity properties, in this study, we attempted the rapid adhesion of poly(vinyl alcohol) (PVA) hydrogels to each other by using an electric field and water-soluble intermediate phenylboronic acid copolymers. PVA hydrogels adhered to each other following the electrophoretic manipulation of poly(3-methacrylamidophenylboronic acid-co-N,N-dimethylacrylamide) copolymers at the interface of the PVA hydro gels. The adhered PVA interface was stable under the physiological conditions, but detachment was observed in the presence of an excess amount of sugar and acid. Detached gels re-adhered under the same conditions, indicating that the adhesion of the hydrogels exhibits repeatability. The electrophoretic adhesion of PVA and related hydrogels may be useful in the field of tissue engineering for the development of on-demand 3D scaffolds.