OLFACTORY GRANULE CELL-DEVELOPMENT IN NORMAL AND HYPER-THYROID RATS
OLFACTORY GRANULE CELL-DEVELOPMENT IN NORMAL AND HYPER-THYROID RATS
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DOI：
10.1016/0165-3806(82)90153-5
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
GREENOUGH, WT
中科院分区：
文献类型：
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作者：
BRUNJES, PC;SCHWARK, HD;GREENOUGH, WT
在出生后第1-4天用1μg/g体重的L-甲状腺素钠处理的正常7日龄、14日龄、21日龄和60日龄大鼠和同窝小鼠的嗅球中检查树突发育。通过高尔基-考克斯技术处理组织，并对二尖瓣和内层颗粒细胞发育进行定量分析。选择这些颗粒细胞群是因为它们的晚期增殖模式表明对出生后激素变化可能更敏感。尽管新生儿甲状腺功能亢进症会导致广泛的成熟加速，包括化学敏感性早熟，但与同窝对照相比，颗粒细胞发育并未受到影响。正常组和甲状腺功能亢进组均表现出倒 U 形的细胞发育模式，在测试的最早年龄期间发生快速树突生长和扩张，但在第 21 天后发生突起和树突区域大小的损失。
Dendritic development was examined in olfactory bulbs of both normal 7-, 14-, 21- and 60-day-old rats and littermates treated on postnatal days 1-4 with 1 .mu.g/g body wt of L-thyroxine sodium. Tissue was processed via the Golgi-Cox technique and subjected to quantitative analyses of mitral and internal layer granule cell development. These populations of granule cells were selected because their pattern of late proliferation suggested potentially greater susceptibility to postnatal hormonal alterations. Although neonatal hyperthyroidism induces widespread acceleration of maturation, including precocious chemosensitivity, granule cell development was unaffected relative to littermate controls. Both normal and hyperthyroid groups exhibited an inverted U-shaped pattern of cellular development, with rapid dendritic growth and expansion occurring during the earliest ages tested, but with loss of processes and dendritic field size occurring after day 21.