Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
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DOI：
10.1530/eje-12-0039
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发表时间：
2012-07-01
影响因子：
5.8
通讯作者：
Andersen, Birgitte
中科院分区：
文献类型：
--
作者：
Vienberg, Sara G.;Brons, Charlotte;Andersen, Birgitte
目的：成纤维细胞生长因子21（Fibroblast growth factor 21，FGF21）是一种参与糖脂代谢的代谢因子。研究设计和方法：20名健康的低出生体重（LBW）且已知有患2型糖尿病风险的年轻男性和26名对照（正常出生体重（NBW））的年轻男性进行5天的高脂肪（HF）过量喂养（+50%）。在饮食前后检查基础和钳夹胰岛素刺激的血清FGF 21水平，并分别在肌肉和脂肪活检中测量FGF 21 mRNA表达。结果：HF组5天内过度喂食饲料显著（P
Objective: Fibroblast growth factor 21 (FGF21) is a metabolic factor involved in glucose and lipid metabolism. However, little is known about the physiological role of FGF21 during a dietary challenge in humans.Research design and methods: Twenty healthy low birth weight (LBW) with known risk of type 2 diabetes and 26 control (normal birth weight (NBW)) young men were subjected to 5 days of high-fat (HF) overfeeding (+50%). Basal and clamp insulin-stimulated serum FGF21 levels were examined before and after the diet, and FGF21 mRNA expression was measured in muscle and fat biopsies respectively. Results: Five days of HF overfeeding diet significantly (P