Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells.
Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells.
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DOI：
10.1149/04520.0065ecst
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Chiang LY
中科院分区：
文献类型：
--
作者：
Huang L;Wang M;Sharma SK;Sperandio FF;Maragani S;Nayka S;Chang J;Hamblin MR;Chiang LY
研究了新型水溶性十阳离子富勒烯单加合物C60[>M(C3N6+C3)2]和C70[>M(C3N6+C3)2]对致病菌和癌细胞的光动力失活作用。在臂区存在大量供电子碘离子作为季铵盐的一部分时，我们发现除了单线态氧（1O2）外，C70[>M(C3N6+C3)2]比C60[>M(C3N6+C3)2]产生更高活性的HO•自由基。这一发现解释了C60[>M(C3N6+C3)2]和C70[>M(C3N6+C3)2]对革兰氏阳性菌和革兰氏阴性菌的优先杀伤作用。假设1O2可以更容易地扩散到革兰氏阳性菌的多孔细胞壁中到达敏感部位，而更不容易渗透的革兰氏阴性菌细胞壁需要更活跃的HO•才能造成真正的损伤。
Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C3N6+C3)2] and C70[>M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6+C3)2] produced more highly reactive HO• radical than C60[>M(C3N6+C3)2], in addition to singlet oxygen (1O2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6+C3)2] and C70[>M(C3N6+C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO• to cause real damage.