Angiogenesis markers quantification in breast cancer and their correlation with clinicopathological prognostic variables.
Angiogenesis markers quantification in breast cancer and their correlation with clinicopathological prognostic variables.
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DOI：
10.1007/s12253-011-9387-6
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Kruk-Jeromin J
中科院分区：
文献类型：
--
作者：
Rykala J;Przybylowska K;Majsterek I;Pasz-Walczak G;Sygut A;Dziki A;Kruk-Jeromin J
肿瘤血管生成对乳腺癌细胞的生长和扩散是必不可少的。因此，本研究的目的是评估血管生成标记物在肿瘤中的诊断性能以及它们在乳腺癌患者血清中的反映水平。FASTQuant血管生成因子复合蛋白分析法检测血管生成素、血管紧张素2、成纤维细胞生长因子碱性、细胞间黏附分子1、角质形成细胞生长因子、血小板衍生生长因子BB和血管内皮生长因子A。我们观察到乳腺癌患者肿瘤组织中PDGF-BB、bFGF和VEGF水平较高，TIMP-1和Ang-2水平极高，而乳腺癌患者血清中Ang-2、PDGF-BB、bFGF、ICAM-1和VEGF水平明显高于乳腺良性疾病患者。此外，在乳腺癌患者的肿瘤和血清中评估的这些血管生成标志物中的一些与标准临床参数、ER状态以及肿瘤的MVD相关。血管生成标记物在肿瘤的生长、侵袭和转移中发挥重要作用。提示联合检测乳腺癌患者肿瘤和血清中的血管生成标记物有助于提高乳腺癌的诊断水平和预后。
Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases.
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影响因子：
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作者：
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