Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients
Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients
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CYP2C9、VKORC1、ApoE 和 ABCB1 多态性对中国老年患者稳定华法林剂量需求的影响
DOI：
10.2217/pgs-2019-0139
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发表时间：
2020-01-01
期刊：
影响因子：
2.1
通讯作者：
Dong, Jing
中科院分区：
文献类型：
--
作者：
Li, Wenyan;Zhao, Ping;Dong, Jing
目的：分析非遗传因素和基因多态性对上海汉族老年患者华法林剂量需求的影响。材料和方法：CYP2C9基因型（rs1799853和rs1057910），FPGS（rs7856096），ApoE（rs7412和rs429358），GGCX（rs699664和rs12714145），EPHX 1（rs4653436、rs1877724、rs1051740和rs1131873），NQO1方法：对214例华法林稳定剂量组患者的血清总胆红素（rs1800566和rs10517）、ABCB 1（rs1045642）、VKORC 1（rs9923231）和CYP4F2（rs2108622）进行测定，并记录其人口学特征。结果如下：多元线性回归分析显示，VKORC 1 rs9923231、CYP 2C 9 *3 rs1057910、Apoe rs7412、年龄、BMI和伴随使用的胺碘酮可以解释每日稳定华法林剂量37.0%的个体差异。结论：VKORC1 rs9923231、CYP2C9*3 rs1057910、ApoE rs7412、年龄、BMI和合并胺碘酮是影响上海汉族老年患者华法林剂量稳定性的重要因素，而ABCB 1 rs1045642不是显著的遗传因素。
Aim: To analyze the impact of nongenetic factors and gene polymorphisms on warfarin dose requirements in elderly Shanghai Han Chinese patients. Materials & methods: Genotypes of CYP2C9 (rs1799853 and rs1057910), FPGS (rs7856096), ApoE (rs7412 and rs429358), GGCX (rs699664 and rs12714145), EPHX1 (rs4653436, rs1877724, rs1051740 and rs1131873), NQO1 (rs1800566 and rs10517), ABCB1 (rs1045642), VKORC1 (rs9923231) and CYP4F2 (rs2108622) in 214 patients with stable warfarin dose were determined and their demographic characteristics were recorded. Results: Multiple linear regression analysis revealed that VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone could explain 37.0% of the individual variations of daily stable warfarin dose. Conclusion:VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone play an important role in stable dose variation of warfarin in elderly Shanghai Han Chinese patients, whereas ABCB1 rs1045642 is not a significant genetic factor.