Effects of angiotensin II, K+, adrenocorticotropin, serotonin, adenosine 3',5'-monophosphate, guanosine 3',5'-monophosphate, A23187, and EGTA on aldosterone synthesis and phospholipid metabolism in the rat adrenal zona glomerulosa.
Effects of angiotensin II, K+, adrenocorticotropin, serotonin, adenosine 3',5'-monophosphate, guanosine 3',5'-monophosphate, A23187, and EGTA on aldosterone synthesis and phospholipid metabolism in the rat adrenal zona glomerulosa.
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血管紧张素 II、K、促肾上腺皮质激素、血清素、3,5-单磷酸腺苷、3,5-单磷酸鸟苷、A23187 和 EGTA 对大鼠肾上腺球状带醛固酮合成和磷脂代谢的影响。
DOI：
10.1210/endo-113-4-1377
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发表时间：
1983
期刊：
影响因子：
4.8
通讯作者：
C. Gomez
中科院分区：
文献类型：
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作者：
R. Farese;R. Larson;M. Sabir;C. Gomez
用血管紧张素II(A-II)、促肾上腺皮质激素(ACTH)、K+、(Bu)2cAMP、(Bu)2cGMP、A23187和5-羟色胺体外孵育大鼠肾上腺肾小球细胞和胶囊，比较它们对类固醇合成和磷脂代谢的影响。在肾小球细胞和胶囊中，A-II、ACTH、K+、(Bu)2cAMP和5-羟色胺均可促进醛固酮或皮质酮的合成，但只有A-II、K+和5-羟色胺显著且持续地增加磷脂酸(PA)和磷脂酰肌醇(PI)对[32P]PI的掺入。A-II、ACTH、K+、(Bu)2cAMP和5-羟色胺均可使肾上腺包膜PI质量增加近2倍。(BU)2cGMP对肾小球磷脂代谢或醛固酮生成的影响相对较小。肾上腺囊膜中K+对[~(32)P]PI掺入PA和PI的影响可被EGTA抑制，而A-II对[~(32)P]PI掺入的影响不受EGTA的影响，但对类固醇合成有抑制作用。放线菌亚胺也能抑制类固醇的合成，但是...
Rat adrenal glomerulosa cells and capsules were incubated in vitro with angiotensin II (A-II), ACTH, K+, (Bu)2cAMP, (Bu)2cGMP, A23187, and serotonin to compare their effects on steroidogenesis and phospholipid metabolism. In both glomerulosa cells and capsules, A-II, ACTH, K+, (Bu)2cAMP, and serotonin enhanced aldosterone or corticosterone production, but only A-II, K+, and serotonin significantly and consistently increased the incorporation of [32P]Pi into phosphatidic acid (PA) and phosphatidylinositol (PI). A-II, ACTH, K+, (Bu)2cAMP, and serotonin all provoked nearly 2- fold increases in PI mass in adrenal capsules. (Bu)2cGMP had relatively small effects, if any, on aldosterone production or glomerulosa phospholipid metabolism. In adrenal capsules, the effects of K+ on [32P]Pi incorporation into PA and PI were inhibited by EGTA, but the effects of A-II on [32P]Pi incorporation were not influenced by EGTA, despite observed inhibition of steroidogenesis. Cycloheximide also inhibited steroidogenesis, but ...
甲状旁腺激素对肾脏磷酸肌醇代谢的刺激是一种不依赖于环核苷酸的作用。
DOI：
10.1016/0005-2760(82)90342-3
发表时间：
1982
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Meltzer,V;Weinreb,S;Bellorin-Font,E;Hruska,KA
通讯作者：
Hruska,KA