Effect of statins on atherosclerotic plaque
Effect of statins on atherosclerotic plaque
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DOI：
10.1016/j.tcm.2019.01.001
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发表时间：
2019-11-01
影响因子：
9.3
通讯作者：
Budoff, Matthew
中科院分区：
文献类型：
--
作者：
Almeida, Shone O.;Budoff, Matthew
降脂治疗一直是降低和预防心血管风险的支柱。他汀类药物已被证明可降低血清胆固醇，沿着心血管疾病发病率和死亡率的显著降低。这些益处是否纯粹是通过降脂或多效性（不依赖胆固醇）作用，尚未完全了解。从血管内超声到多探测器冠状动脉计算机断层扫描血管造影术，心脏成像的进展加深了我们对他汀类药物对动脉粥样硬化斑块作用的理解。值得注意的是，他汀类药物在斑块消退中发挥作用，降低脂质含量。这些药物进一步稳定了动脉粥样硬化斑块，增厚的纤维帽和大钙化起到稳定动脉粥样硬化的作用。(C)2019爱思唯尔公司All rights reserved.
Lipid lowering therapy has been the mainstay of cardiovascular risk reduction and prevention. Statin drugs have been shown to reduce serum cholesterol along with significant reduction in morbidity and mortality of cardiovascular disease. Whether these benefits are purely through lipid lowering or pleiotropic (cholesterol independent) effects has yet to be fully understood. Advances in cardiac imaging, from intravascular ultrasound to multi-detector coronary computed tomography angiography, have furthered our understanding of statin's effect on atherosclerotic plaque. Notably, statins play a role in plaque regression with reduction in lipid content. These drugs further stabilize atherosclerotic plaque with thickened fibrous caps and macrocalcification that serves to stabilize atheromas. (C) 2019 Elsevier Inc. All rights reserved.