A test-retest study on Parkinson's PPMI dataset yields statistically significant white matter fascicles.
A test-retest study on Parkinson's PPMI dataset yields statistically significant white matter fascicles.
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DOI：
10.1016/j.nicl.2017.07.020
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Descoteaux M
中科院分区：
文献类型：
--
作者：
Cousineau M;Jodoin PM;Morency FC;Rozanski V;Grand'Maison M;Bedell BJ;Descoteaux M
在这项工作中，我们提出了一个扩散MRI协议，用于挖掘帕金森病扩散MRI数据集，并恢复强大的疾病特异性生物标志物。使用先进的高角分辨率扩散成像（HARDI）交叉纤维建模和纤维束成像鲁棒部分容积效应，我们自动解剖了50个白色物质（WM）束。这些神经束将深部核团（丘脑、壳核、苍白球）连接到不同的皮质功能区（联想、运动、感觉运动、边缘）、基底前脑和黑质。然后，在这50个候选WM分册中，只有那些通过了测试-重测再现性程序的才有资格进行进一步的追踪分析。利用超过600名受试者的独特的2时间点测试-重测帕金森氏进展标志物倡议（PPMI）数据集，我们发现帕金森氏病患者和健康对照者之间沿着皮质下-皮质通路的束轮廓存在统计学显著差异。特别是，显着增加FA，表观纤维密度，束密度和广义FA中检测到的一些位置的黑-丘脑底-丘脑-皮质途径。这种连接是平衡电机输出协调的主要电机电路之一。因此，在这些领域的WM分册的详细和可量化的知识是必不可少的，以提高脑深部电刺激的质量和结果，并针对新的WM位置进行调查。提出了一种用于恢复稳健的疾病特异性生物标志物的扩散MRI协议。对50个解剖的WM束进行了重测重现性评估。对这些稳健的纤维束进行纤维束测量结果的统计分析。差异存在于沿着黑质-丘脑底核-垂体-丘脑-皮质通路。这些结果对于改善现有的治疗方法如脑深部电刺激至关重要。
In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra. Then, among these 50 candidate WM fascicles, only the ones that passed a test-retest reproducibility procedure qualified for further tractometry analysis. Leveraging the unique 2-timepoints test-retest Parkinson's Progression Markers Initiative (PPMI) dataset of over 600 subjects, we found statistically significant differences in tract profiles along the subcortico-cortical pathways between Parkinson's disease patients and healthy controls. In particular, significant increases in FA, apparent fiber density, tract-density and generalized FA were detected in some locations of the nigro-subthalamo-putaminal-thalamo-cortical pathway. This connection is one of the major motor circuits balancing the coordination of motor output. Detailed and quantifiable knowledge on WM fascicles in these areas is thus essential to improve the quality and outcome of Deep Brain Stimulation, and to target new WM locations for investigation. A diffusion MRI protocol to recover robust disease-specific biomarkers is proposed. A test-retest reproducibility assessment is applied to 50 dissected WM fascicles. Statistical analysis of tractometry results is performed on these robust fascicles. Differences are found along the nigro-subthalamo-putaminal-thalamo-cortical pathway. These results are crucial to improve existing treatments like Deep Brain Stimulation.
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影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
5.7
作者：
Calamante, Fernando;Smith, Robert E.;Connelly, Alan
通讯作者：
Connelly, Alan
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR
影响因子：
4.8
作者：
Friedman, Lee;Stern, Hal;Potkin, Steven G.
通讯作者：
Potkin, Steven G.
影响因子：
4.8
作者：
Dell'Acqua, Flavio;Simmons, Andrew;Catani, Marco
通讯作者：
Catani, Marco