Purity of synthetic cannabinoids sold online for recreational use.
Purity of synthetic cannabinoids sold online for recreational use.
复制标题
在线销售的用于娱乐用途的合成大麻素的纯度。
DOI：
10.1093/jat/bkr018
复制
发表时间：
2012
影响因子：
2.5
通讯作者：
Javors,MartinA
中科院分区：
文献类型：
--
作者：
Ginsburg,BrettC;McMahon,LanceR;Sanchez,JesusJ;Javors,MartinA
合成大麻素的娱乐用途最近有所增加。这一增长的部分原因是，最近可在网上合法批量销售廉价化合物。特别是，JWH-018（1-戊基-3-（1-萘甲酰基）吲哚）和JWH-073（1-丁基-3-（1-萘甲酰基）吲哚）已被发现在作为大麻替代品销售的草药混合物中。尽管这些特定的化合物最近在美国被紧急安排，但在线供应商已经将销售转移到其他类似的化合物，而这些化合物目前还没有被安排。然而，从网上供应商获得的药物纯度尚不清楚。采用高效液相色谱法和紫外检测器以及从传统研究化学品供应商获得的经验证标准品，测定了来自三个不同在线供应商的JWH-018和JWH-073的相对纯度。我们的结果表明，从在线供应商获得的JWH-018和JWH-073具有与经验证的标准品相当的纯度，即使其物理性质在颜色、质地和气味上不同。得出的结论是，消费合成大麻素制剂后发生的不良事件不太可能是由于制造过程中的杂质或残留物，而是由于活性药物的影响或与作为大麻替代品销售的产品中掺入的草药中的其他精神活性化学品的相互作用。
The recreational use of synthetic cannabinoids has recently increased. This increase is due, in part, to the recent availability of inexpensive compound sold legally online in bulk. In particular, JWH-018 (1-pentyl-3-(1-naphthoyl)indole) and JWH-073 (1-butyl-3-(1-naphthoyl)indole) have been found in herbal blends marketed as alternatives to cannabis. Although these particular compounds have recently been emergency scheduled in the United States, online suppliers have shifted sales to other, similar compounds that are not currently scheduled. However, the purity of the drugs obtained from online suppliers is not known. Relative purity of JWH-018 and JWH-073 from three different online suppliers was determined using high-performance liquid chromatography with ultraviolet detection and validated standards obtained from a traditional research chemical supplier. Our results show that JWH-018 and JWH-073 obtained from online vendors was of comparable purity to validated standards, even though the physical properties varied in color, texture, and odor. It is concluded that adverse events following consumption of synthetic cannabinoid preparations is unlikely to be due to impurities or residue from the manufacturing process, but rather to effects of the active drug or interactions with other psychoactive chemicals from herbs blended into products marketed as cannabis alternatives.