Ontogenetic Differences in Adolescent and Adult C57BL/6J and DBA/2J Mice: Anxiety-Like, Locomotor, and Consummatory Behaviors
Ontogenetic Differences in Adolescent and Adult C57BL/6J and DBA/2J Mice: Anxiety-Like, Locomotor, and Consummatory Behaviors
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DOI：
10.1002/dev.20501
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发表时间：
2011-03-01
影响因子：
2.2
通讯作者：
Boehm, Stephen L., II
中科院分区：
文献类型：
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作者：
Moore, Eileen M.;Linsenbardt, David N.;Boehm, Stephen L., II
青春期是一个高度保守的时期，在此期间哺乳动物经历了许多荷尔蒙、生物学和行为的变化[Spear[2000]Neurosci。生物行为。启示录24：417-463]。伦理限制限制了可以在人类青少年身上进行的研究。啮齿动物至少为青春期的一些特征提供了一个有用的模型，包括身体生长的增加，睡眠/醒来的差异，饮食模式的差异，以及冒险、寻求新奇和探索行为的差异。许多现有的发育研究都利用了大鼠；然而，使用近亲交配的小鼠品系提供了一种独特的方法来评估与青春期行为差异有关的遗传因素。我们使用两个常用的近交系小鼠，DBA/2J和C57BL/6J品系，评估了成年人和青少年在焦虑样行为、运动行为和吞噬行为方面的差异。在测量的所有三种行为中，都发现了年龄和基因相关的差异，这表明这两个因素都是小鼠行为的重要决定因素。(C)2010 Wiley期刊，Inc.开发心理学杂志53：141-156,2011。
Adolescence is a highly conserved period during which mammals undergo a number of hormonal, biological, and behavioral changes [Spear [2000] Neurosci. Biobehav. Rev. 24: 417-463]. Ethical constraints limit the research that can be done in human adolescents. Rodents provide a useful model of at least some of the features of adolescence, including increases in body growth, differences in sleep/wake, and eating patterns, as well as differences in risk-taking, novelty seeking, and exploratory behaviors. Much of the available developmental research has utilized rats; however, the use of inbred mouse strains provides a unique means to assess the genetic factors involved in behavioral differences during adolescence. We assessed differences between adults and adolescents in anxiety-like, locomotor, and consummatory behaviors using two commonly used inbred strains of mice, the DBA/2J and C57BL/6J strains. Age and genotype-dependent differences were found in all three behaviors measured, suggesting both factors are important determinants of behavior in mice. (C) 2010 Wiley Periodicals, Inc. Dev Psychobiol 53: 141-156, 2011.