ANTIGENIC RELATIONSHIP OF FELINE INFECTIOUS PERITONITIS VIRUS TO CORONAVIRUSES OF OTHER SPECIES
ANTIGENIC RELATIONSHIP OF FELINE INFECTIOUS PERITONITIS VIRUS TO CORONAVIRUSES OF OTHER SPECIES
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DOI：
10.1007/bf01315534
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发表时间：
1978-01-01
影响因子：
2.7
通讯作者：
MENGELING, WL
中科院分区：
文献类型：
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作者：
PEDERSEN, NC;WARD, J;MENGELING, WL
应用直接和间接荧光抗体法，研究了猫传染性腹膜炎病毒（FIPV）与其他7种人、动物冠状病毒的抗原关系。FIPV与猪传染性胃肠炎病毒（TGEV）关系密切。传染性胃肠炎病毒和FIPV与人冠状病毒229 E（HCV-229 E）和犬冠状病毒（CCV）抗原性相关。该研究中一个有趣的发现是，本研究选择的8种冠状病毒属于2个抗原性不同的组之一。各组病毒之间存在不同程度的抗原相关性，但与第二组冠状病毒抗原无关。第一抗原相关组包括小鼠肝炎病毒3型（MHV-3）、猪血凝性脑脊髓炎病毒67 N（HEV-67 N）、小牛腹泻冠状病毒（CDCV）和人冠状病毒OC 43（HCV-OC 43）。第二类抗原相关组包括FIPV、TGEV、HCV-229 E和CCV。
Utilizing the direct and indirect fluorescent antibody procedure, the antigenic relationship of the feline infectious peritonitis virus (FIPV) to 7 other human and animal coronaviruses was studied. FIPV was closely related to transmissible gastroenteritis virus (TGEV) of swine. Transmissible gastroenteritis virus and FIPV were in turn antigenically related to human coronavirus 229 E (HCV-229 E) and canine coronavirus (CCV). An interesting finding in the study was that the 8 coronaviruses selected for this study fell into 1 of 2 antigenically distinct groups. Viruses in each group were antigenically related to each other to varying degrees, but were antigenically unrelated to coronaviruses of the 2nd group. The 1st antigenically related group was comprised of mouse hepatitis virus type 3 (MHV-3), hemagglutinating encephalomyelitis virus 67N (HEV-67N) of swine, calf diarrhea coronavirus (CDCV) and human coronavirus OC43 (HCV-OC43). The 2nd antigenically related group was comprised of FIPV, TGEV, HCV-229E and CCV.