Proliferation of T gamma cells with killer-cell activity in two patients with neutropenia and recurrent infections.
Proliferation of T gamma cells with killer-cell activity in two patients with neutropenia and recurrent infections.
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两名患有中性粒细胞减少症和反复感染的患者体内具有杀伤细胞活性的 T γ 细胞的增殖。
DOI：
10.1056/nejm198004243021702
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
C. Melief
中科院分区：
文献类型：
--
作者：
A. Bom‐Van Noorloos;H. Pegels;R. V. van Oers;J. Silberbusch;T. Feltkamp;R. Goudsmit;W. Zeijlemaker;A. von dem Borne;C. Melief
Two patients with severe granulocytopenia and recurrent infections of the skin and oropharynx had excess T lymphocytes with receptors for the Fc portion of IgG (T gamma cells) in blood and bone marrow. The abnormal T gamma cells killed antibody-sensitized target cells in vitro (killer-cell activity) but did not suppress immunoglobulin production by B lymphocytes (suppressor-cell activity). T gamma lymphocytes from normal persons showed both killer-cell activity and suppressor-cell activity. In the serum of one patient, granulocyte antibodies, possibly of an autoimmune nature, were detected. The clinical picture in conjunction with the hematologic and immunologic findings characterized the disease of both patients as a distinct entity among the chronic lymphoproliferative diseases of T-cell origin.
