Selective Michael Reaction Controlled by Supersilyl Protecting Group
Selective Michael Reaction Controlled by Supersilyl Protecting Group
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DOI：
10.1002/anie.201503574
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发表时间：
2015-07-20
影响因子：
16.6
通讯作者：
Yamamoto, Hisashi
中科院分区：
文献类型：
--
作者：
Izumiseki, Atsuto;Yamamoto, Hisashi
报道了有机锂试剂与甲基丙烯酸超硅酯的选择性Michael反应。该方法能够控制单迈克尔加成和双迈克尔加成。使用超硅基保护基团的过程的成功终止允许控制的、化学选择性的和非对映选择性的Michael反应。
Selective Michael reaction of organolithium reagents to supersilyl methacrylate is reported. The method was able to control a single and double Michael addition. The successful termination of the process using the supersilyl protecting group allows for the controlled, chemoselective, and diastereoselective Michael reaction.