Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder
Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder
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DOI：
10.1161/strokeaha.108.516112
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发表时间：
2008-12-01
期刊：
影响因子：
8.3
通讯作者：
Kuroda, Yasuo
中科院分区：
文献类型：
--
作者：
Yakushiji, Yusuke;Nishiyama, Masanori;Kuroda, Yasuo
背景和目的：认知功能障碍和脑微出血（MB）之间的关系越来越受到关注。因为所有以前的研究都调查了神经系统疾病的患者，我们检查了没有神经系统疾病的主题，以澄清致病relationships. Methods，共518个连续的成年人没有神经系统疾病谁经历了健康筛查测试的大脑进行了前瞻性研究。使用1.5-T系统的回波T2* 加权MRI检测MB。进行简易精神状态检查（MMSE）以确定认知功能。MMSE评分< 27 or >低于年龄相关的平均值1.5 SD被视为低于normal. Results-MB被发现在35名（6.8%）。MMSE评分< 27分者25例（4.8%），低于年龄相关平均值1.5SD者34例（6.6%）。单变量分析显示MB的存在和数量、受教育时间短和严重的白色高信号与低于正常值评分显著相关。在逻辑回归分析中，MB的存在（比值比[OR]，5.44; 95%CI，1.83至16.19）和MB的数量（OR，1.32; 95%CI，1.04至1.68）仍然显示与MMSE评分< 27显著相关。Logistic回归分析显示，MB的存在（OR，3.93; 95%CI，1.44至10.74）和数量（OR，1.26; 95%CI，1.01至1.59）与MMSE评分低于年龄相关平均值> 1.5 SD之间存在显著相关性。在MMSE分项评分中，“注意力和计算”在MB阳性受试者中显著降低（P=0.017）。（中风。2008; 39：3323-3328）。
Background and Purpose-Increasing attention has been paid to associations between cognitive dysfunction and brain microbleeds (MBs). Because all previous studies have investigated patients with neurological disorders, we examined subjects without neurological disorder in order to clarify pathogenic relationships.Methods-A total of 518 consecutive adults without neurological disorder who had undergone health-screening tests of the brain were studied prospectively. Gradient-echo T2*-weighted MRI using a 1.5-T system was used to detect MBs. The Mini-Mental State Examination (MMSE) was administered to determine cognitive functions. MMSE scores < 27 or > 1.5 SDs below the age-related mean were regarded as subnormal.Results-MBs were found in 35 subjects (6.8%). MMSE score < 27 was found in 25 subjects (4.8%), with MMSE score > 1.5 SDs below the age-related mean in 34 subjects (6.6%). Univariate analysis showed presence and number of MBs, short duration of education, and severe white matter hyperintensities as significantly associated with subnormal scores. In logistic regression analysis, presence of MBs (odds ratio [OR], 5.44; 95% CI, 1.83 to 16.19) and number of MBs (OR, 1.32; 95% CI, 1.04 to 1.68) still displayed significant associations with MMSE score < 27. Logistic regression analysis revealed a significant relationship between presence (OR, 3.93; 95% CI, 1.44 to 10.74) and number (OR, 1.26; 95% CI, 1.01 to 1.59) of MBs and MMSE score > 1.5 SDs below the age-related mean. Among MMSE subscores, "attention and calculation" was significantly lower in MB-positive subjects (P=0.017).Conclusions-MBs appear to be primarily associated with global cognitive dysfunction. (Stroke. 2008; 39: 3323-3328.)