Abnormalities of Inter- and Intra-Hemispheric Functional Connectivity in Autism Spectrum Disorders: A Study Using the Autism Brain Imaging Data Exchange Database.
Abnormalities of Inter- and Intra-Hemispheric Functional Connectivity in Autism Spectrum Disorders: A Study Using the Autism Brain Imaging Data Exchange Database.
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DOI：
10.3389/fnins.2016.00191
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发表时间：
2016
影响因子：
4.3
通讯作者：
Cheon KA
中科院分区：
文献类型：
--
作者：
Lee JM;Kyeong S;Kim E;Cheon KA
最近，自闭症脑成像数据交换(ABIT)项目显示，与典型发育对照(TDC)相比，自闭症谱系障碍(ASD)患者的功能连接性降低。然而，ASD受试者的功能性连接不足的来源是否同样由同侧和对侧大脑部分造成仍是值得怀疑的。在这项研究中，我们分解了大脑半球间和大脑内区域，并比较了458名ASD患者和517名ASD患者的功能连接密度(FCD)。我们通过分别计算与大脑相反和相同半球区域的所有体素的功能连接数量来量化大脑中的半球间和半球内的FCDs。与tDCs相比，ASD患者后扣带回、舌回/海马旁回和中央后回的大脑半球间和半球内FCDs均显著减少。此外，在ASD组中，自闭症诊断观察计划(ADOS-RRB)的限制和重复行为分值与舌/海马区平均大脑半球间FCD和对侧FCD呈显著负相关。此外，ADOS-RRB评分与默认模式网络区域如后扣带皮质和楔前叶的平均对侧FCD呈显著负相关。综上所述，我们的研究结果表明，ASD的非社会功能加工缺陷，如限制性和重复性行为以及感觉过敏，可以通过大脑半球间和大脑内部的功能分离来确定。
Recently, the Autism Brain Imaging Data Exchange (ABIDE) project revealed decreased functional connectivity in individuals with Autism Spectrum Disorders (ASD) relative to the typically developing controls (TDCs). However, it is still questionable whether the source of functional under-connectivity in subjects with ASD is equally contributed by the ipsilateral and contralateral parts of the brain. In this study, we decomposed the inter- and intra-hemispheric regions and compared the functional connectivity density (FCD) between 458 subjects with ASD and 517 TDCs from the ABIDE database. We quantified the inter- and intra-hemispheric FCDs in the brain by counting the number of functional connectivity with all voxels in the opposite and same hemispheric brain regions, respectively. Relative to TDCs, both inter- and intra-hemispheric FCDs in the posterior cingulate cortex, lingual/parahippocampal gyrus, and postcentral gyrus were significantly decreased in subjects with ASD. Moreover, in the ASD group, the restricted and repetitive behavior subscore of the Autism Diagnostic Observation Schedule (ADOS-RRB) score showed significant negative correlations with the average inter-hemispheric FCD and contralateral FCD in the lingual/parahippocampal gyrus cluster. Also, the ADOS-RRB score showed significant negative correlations with the average contralateral FCD in the default mode network regions such as the posterior cingulate cortex and precuneus. Taken together, our findings imply that a deficit of non-social functioning processing in ASD such as restricted and repetitive behaviors and sensory hypersensitivity could be determined via both inter- and intra-hemispheric functional disconnections.