Endocannabinoid signaling and long-term synaptic plasticity.
Endocannabinoid signaling and long-term synaptic plasticity.
复制标题
DOI：
10.1146/annurev.physiol.010908.163149
复制
发表时间：
2009
影响因子：
18.2
通讯作者：
Castillo PE
中科院分区：
文献类型：
--
作者：
Heifets BD;Castillo PE
内源性大麻素（eCB）是调节整个CNS突触传递的关键活性依赖性信号。因此，eCB参与从进食稳态到认知的神经功能。人们对了解外源性（例如大麻）和内源性大麻素如何影响行为非常感兴趣。由于行为适应被广泛认为依赖于突触强度的变化，因此在整个大脑的突触中eCB介导的长期抑制（eCB-LTD）的流行值得密切关注。eCB-LTD的诱导和表达虽然在各种突触中非常相似，但受到一系列调控影响的控制，我们刚刚开始发现。这种复杂性赋予了eCB-LTD重要的计算特性，如重合检测和输入特异性，这对学习和记忆等更高的CNS功能至关重要。在这篇文章中，我们审查的主要分子和细胞机制eCB-LTD，以及潜在的生理相关性，这种广泛的形式的突触可塑性。
Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the CNS. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition. There is great interest in understanding how exogenous (e.g. cannabis) and endogenous cannabinoids affect behavior. As behavioral adaptations are widely considered to rely on changes in synaptic strength, the prevalence of eCB-mediated long term depression (eCB-LTD) at synapses throughout the brain merits close attention. The induction and expression of eCB-LTD, while remarkably similar at various synapses, is controlled by an array of regulatory influences which we are just beginning to uncover. This complexity endows eCB-LTD with important computational properties, such as coincidence detection and input specificity, critical for higher CNS functions like learning and memory. In this article, we review the major molecular and cellular mechanisms underlying eCB-LTD, as well as the potential physiological relevance of this widespread form of synaptic plasticity.
登录
查看更多内容
影响因子：
25
作者：
Allen, CB;Celikel, T;Feldman, DE
通讯作者：
Feldman, DE
影响因子：
5.3
作者：
Bender, VA;Bender, KJ;Feldman, DE
通讯作者：
Feldman, DE
影响因子：
16.2
作者：
Cachope, Roger;Mackie, Ken;Pereda, Alberto E.
通讯作者：
Pereda, Alberto E.
影响因子：
5.3
作者：
Bender, KJ;Allen, CB;Feldman, DE
通讯作者：
Feldman, DE
影响因子：
16.2
作者：
Brenowitz, SD;Regehr, WG
通讯作者：
Regehr, WG