THERMOGENIC DRUGS FOR THE TREATMENT OF OBESITY - SYMPATHETIC STIMULANTS IN ANIMAL-MODELS
THERMOGENIC DRUGS FOR THE TREATMENT OF OBESITY - SYMPATHETIC STIMULANTS IN ANIMAL-MODELS
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DOI：
10.1079/bjn19840087
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
MILLER, DS
中科院分区：
文献类型：
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作者：
DULLOO, AG;MILLER, DS
已知刺激交感神经系统的药物（33）已被筛选出产热特性。所提供的结果是其中7个。在5种肥胖动物模型（遗传性（小鼠和大鼠），下丘脑（小鼠）和饮食（小鼠和大鼠）以及瘦小鼠中测试了药物。能量平衡的研究进行了比较胴体技术，以及通过测量每天的O消耗。在肥胖动物中，所有7种药物都倾向于降低体重和脂肪，而不损失身体蛋白质：它们通过增加代谢率而不增加食物摄入量来发挥作用。它们对瘦动物的效果要差得多。这些发现支持了肥胖是由于交感神经系统活动减少的概念。在药物的有效性的差异进行了讨论，在肥胖症的动物模型之间的差异。麻黄碱和反苯环丙胺被认为是最有效的药物，在这一系列的实验和初步的情况下，为人类临床试验。
Drugs (33) known to stimulate the sympathetic nervous system have been screened for thermogenic properties. The results presented are for 7 of them. The drugs were tested in 5 animal models of obesity (genetic (mice and rats), hypothalamic (mice) and dietary (mice and rats) as well as in lean mice. Energy-balance studies were undertaken using the comparative-carcass technique as well as by measurement of daily O consumption. All 7 drugs in obese animals tended to reduce body-weight and fat without loss of body protein: they acted by increasing metabolic rate without increasing food intake. They were much less effective in lean animals. These findings lend support to the concept that obesity is due to a diminished activity of the sympathetic nervous system. Differences in the effectiveness of the drugs are discussed in relation to differences between the animal models of obesity. Ephedrine and tranylcypromine were found to be the most effective drugs in this series of experiments and a prima facie case is made for human clinical trials.