Exploring the origin and regulatory role of mast cells in asthma.
Exploring the origin and regulatory role of mast cells in asthma.
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探索肥大细胞在哮喘中的起源和调节作用。
DOI：
10.1097/aci.0000000000000703
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发表时间：
2021-02-01
影响因子：
2.8
通讯作者：
中科院分区：
文献类型：
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作者：
肥大细胞 (MC) 以前被认为仅作为哮喘中的效应细胞，但最近的研究表明，肥大细胞可能在哮喘下呼吸道炎症的传播和调节中发挥更重要的作用。初步研究发现，哮喘患者外周血中肥大细胞祖细胞（MCP）数量增加，这些细胞可能导致哮喘患者气道中祖细胞数量增加。哮喘气道内存在独特的 MC 亚群，其特征在于其物理位置，并以其肥大细胞蛋白酶的表达谱来区分。上皮内 MC 与 2 型 (T2) 炎症密切相关，但其他研究表明抗肥大细胞疗法可作为 T2 低哮喘的治疗方法。最近研究表明，MCs 与气道上皮和气道平滑肌密切沟通，调节下气道炎症和气道高反应性。最近的研究更好地阐明了 MC 在调节下气道炎症和气道高反应性中的核心作用。
Mast cells (MCs) have previously been thought to function solely as effector cells in asthma but more recent studies have indicated that MCs may play a more central role in propagating and regulating lower airway inflammation in asthma. Initial studies have found increased numbers of mast cell progenitors (MCPs) in the peripheral blood of subjects with asthma and these cells could contribute to the increased number of progenitors identified in the airways of subjects with asthma. There are unique subpopulations of MCs within the asthmatic airway which are characterized by their physical location and distinguished by their expression profile of mast cell proteases. Intraepithelial MCs are tightly associated with type-2 (T2) inflammation but additional studies have suggested a role for anti-mast cell therapies as a treatment for T2-low asthma. MCs have recently been shown to closely communicate with the airway epithelium and airway smooth muscle to regulate lower airway inflammation and airway hyperresponsiveness. Recent studies have better illuminated the central role of MCs in regulating lower airway inflammation and airway hyperresponsiveness.