GADD45A expression is correlated with patient prognosis in esophageal cancer
GADD45A expression is correlated with patient prognosis in esophageal cancer
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DOI：
10.3892/ol.2015.3882
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发表时间：
2016-01-01
期刊：
影响因子：
2.9
通讯作者：
Takeyama, Hiromitsu
中科院分区：
文献类型：
--
作者：
Ishiguro, Hideyuki;Kimura, Masahiro;Takeyama, Hiromitsu
食管癌患者的预后仍然很差，肿瘤淋巴结转移分类系统不足以预测患者的预后。因此，需要鉴定新的食管癌预测标志物。本研究探讨了可切除食管鳞状细胞癌（ESCC）中生长停滞和DNA损伤诱导的45 α（GADD 45 A）和p53的临床病理意义。该研究包括2001年至2007年期间接受手术的62名食管癌患者。免疫组化检测GADD 45 A基因产物（GADD 45 A）和p53蛋白的表达。分析GADD 45 A表达与食管鳞癌临床病理因素及预后的关系。GADD 45 A和p53蛋白表达阳性率分别为56.5%（35/62）和48.4%（30/62）。GADD 45 A与p53的表达无明显相关性。然而，GADD 45 A表达与病理分期相关（0-I期与II-IV期; P=0.014），与肿瘤（T）或淋巴结（N）状态无关。此外，GADD 45 A阳性患者的生存率显著高于GADD 45 A阴性患者（对数秩检验，P=0.009）。多变量分析表明，T状态、N状态和GADD 45 A表达是预测生存的重要变量（风险比，2.486; 95%置信区间，1.168-5.290; P=0.018）。总的来说，GADD 45 A表达显著影响ESCC患者的生存率，GADD 45 A表达降低与这些患者根治性手术后的不良预后相关。
The prognosis of patients with esophageal cancer remains poor, and the tumor-node-metastasis classification system is not sufficient for predicting patient prognoses. Therefore, the identification of novel predictive markers for esophageal cancer is required. The present study investigated the clinicopathological significance of growth arrest and DNA damage-inducible 45 alpha (GADD45A) and p53 in resectable esophageal squamous cell carcinoma (ESCC). The study consisted of 62 patients with esophageal cancer who underwent surgery between 2001 and 2007. The expression of the GADD45A gene product (GADD45A) and the p53 protein was analyzed by immunohistochemistry. The correlations among GADD45A expression, clinicopathological factors and prognosis were then analyzed in the patients with ESCC. GADD45A and p53 were expressed in 56.5% (35/62) and 48.4% (30/62) of patients, respectively. The expression of GADD45A did not show a marked correlation with that of p53. However, GADD45A expression correlated with pathological stage (stage 0-I vs. stages II-IV; P=0.014) and did not correlate with the tumor (T) or node (N) status. Furthermore, patients who were positive for GADD45A exhibited a significantly higher survival rate than those who were negative for GADD45A (log-rank test, P=0.009). Multivariate analysis indicated that T status, N status and GADD45A expression were significant variables predicting survival (hazard ratio, 2.486; 95% confidence interval, 1.168-5.290; P=0.018). Overall, GADD45A expression significantly affected the survival of patients with ESCC, and the reduced expression of GADD45A was correlated with a poor prognosis following curative surgery in these patients.