Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer.
Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer.
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DOI：
10.2217/bmm-2016-0209
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发表时间：
2016-11
影响因子：
2.2
通讯作者：
Srivastava S
中科院分区：
文献类型：
--
作者：
Honda K;Srivastava S
鉴于胰腺癌在普通人群中的发病率较低，在普通人群中使用侵入性方式进行胰腺癌筛查是不可行的。胰腺癌及其癌前病变的侵袭性筛查与非侵袭性生物标志物的结合有可能降低胰腺癌的死亡率。在这篇综述中，我们重点介绍在血液中发现的可以指示早期胰腺癌的生物标记物，并讨论目前胰腺癌筛查的策略。我们最近在胰腺癌及其癌前病变中发现了载脂蛋白A2亚型的独特变化，并描述了其作为胰腺癌早期检测和风险分层的潜在生物标志物的临床应用价值。
Given the low incidence of pancreatic cancer in the general population, screening of pancreatic cancer in the general population using invasive modalities is not feasible. Combination of invasive screening with noninvasive biomarkers for pancreatic cancer and its precancerous lesions has the potential to reduce mortality due to pancreatic cancer. In this review, we focus on biomarkers found in the blood that can indicate early-stage pancreatic cancer, and we discuss current strategies for screening for pancreatic cancer. We recently identified a unique alteration in apolipoprotein A2 isoforms in pancreatic cancer and its precancerous lesions, and we describe its clinical usefulness as a potential biomarker for the early detection and risk stratification of pancreatic cancer.