Measuring target detection performance in paradigms with high event rates
Measuring target detection performance in paradigms with high event rates
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DOI：
10.1016/j.clinph.2012.11.012
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发表时间：
2013-05-01
影响因子：
4.7
通讯作者：
Andersen, Soren K.
中科院分区：
文献类型：
--
作者：
Bendixen, Alexandra;Andersen, Soren K.
目的：行为测量和神经生理学测量的结合不可避免地意味着相互制约，例如当神经生理学测量需要快节奏的刺激呈现时，因此行为反应对特定先前刺激的归属变得模糊。我们开发和测试了一种有效评估行为检测性能的方法，尽管存在这种模糊性。方法：我们检查了文献中采用的四种处理此类情况的方法。我们解析地推导出一种新的计算信号检测理论经典参数的变体，命中率和虚警率，适用于快节奏的范例。结果：以前的方法都存在特定的缺陷(对响应窗口选择的敏感性，对行为检测性能的有偏估计)。我们的新方法在模拟行为数据和经验行为数据上都表现出了优越的性能。作为目标检测的电生理指标，行为表现和N2b成分之间的可靠对应提供了进一步的证据。结论：我们的方法的合理性得到了理论和经验的证实。意义：我们展示了一种易于实现的解决方案，用于测量目标检测性能而不依赖于事件呈现的速度。因此，克服了以前方法的测量偏差，我们的方法将有助于澄清不同皮质激活测量的行为相关性。(C)2012年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objectives: Combining behavioral and neurophysiological measurements inevitably implies mutual constraints, such as when the neurophysiological measurement requires fast-paced stimulus presentation and hence the attribution of a behavioral response to a particular preceding stimulus becomes ambiguous. We develop and test a method for validly assessing behavioral detection performance in spite of this ambiguity.Methods: We examine four approaches taken in the literature to treat such situations. We analytically derive a new variant of computing the classical parameters of signal detection theory, hit and false alarm rates, adapted to fast-paced paradigms.Results: Each of the previous approaches shows specific shortcomings (susceptibility towards response window choice, biased estimates of behavioral detection performance). Superior performance of our new approach is demonstrated for both simulated and empirical behavioral data. Further evidence is provided by reliable correspondence between behavioral performance and the N2b component as an electrophysiological indicator of target detection.Conclusions: The appropriateness of our approach is substantiated by both theoretical and empirical arguments.Significance: We demonstrate an easy-to-implement solution for measuring target detection performance independent of the rate of event presentation. Thus overcoming the measurement bias of previous approaches, our method will help to clarify the behavioral relevance of different measures of cortical activation. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.