Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: Report of a workshop at Bethesda, Maryland, December 17-18, 2001.
Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: Report of a workshop at Bethesda, Maryland, December 17-18, 2001.
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DOI：
10.1667/rr3021
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发表时间：
2003-06-01
影响因子：
3.4
通讯作者：
Wong, Rosemary S. L.
中科院分区：
文献类型：
--
作者：
Coleman, C. Norman;Blakely, William F.;Wong, Rosemary S. L.
本讲习班将1-10Gy剂量的辐射定义为中等剂量的辐射，照射可能发生在放射治疗过程中，或作为辐射事故或核/放射性恐怖主义的结果，或单独或与生物恐怖主义一起发生。由此产生的辐射损伤将是一系列分子、细胞、组织和整个动物过程的结果。为解决这些问题的研究现状，召开了一次基础广泛的讲习班。具体建议是：(1)研究：确定从最初的分子损伤到即时和延迟性损伤的关键分子、细胞和组织途径。后者是一个慢性渐进性过程，暴露后治疗是可能的。(2)技术：发展高通量技术，研究辐射暴露后的基因、蛋白质和其他生化表达，以及辐射暴露的细胞遗传学标记，采用快速、准确的技术分析多个样本。(3)治疗策略：确定更多的生物靶点，开发有效的辐射损伤治疗方法。(4)确保足够的专业知识：从辐射生物学、癌症生物学、分子生物学、细胞生物学和伤口愈合等领域招聘和培训研究人员，并鼓励在辐射损伤的机制和治疗方面的跨学科研究方面进行合作。向公众以及参与应对核事故/事件和保护/治疗公众的调查人员、政策制定者和机构传播关于辐射照射影响的知识。
Exposures to doses of radiation of 1-10 Gy, defined in this workshop as moderate-dose radiation, may occur during the course of radiation therapy or as the result of radiation accidents or nuclear/radiological terrorism alone or in conjunction with bioterrorism. The resulting radiation injuries would be due to a series of molecular, cellular, tissue and whole-animal processes. To address the status of research on these issues, a broad-based workshop was convened. The specific recommendations were: (1) Research: Identify the key molecular, cellular and tissue pathways that lead from the initial molecular lesions to immediate and delayed injury. The latter is a chronic progressive process for which postexposure treatment may be possible. (2) Technology: Develop high-throughput technology for studying gene, protein and other biochemical expression after radiation exposure, and cytogenetic markers of radiation exposure employing rapid and accurate techniques for analyzing multiple samples. (3) Treatment strategies: Identify additional biological targets and develop effective treatments for radiation injury. (4) Ensuring sufficient expertise: Recruit and train investigators from such fields as radiation biology, cancer biology, molecular biology, cellular biology and wound healing, and encourage collaboration on interdisciplinary research on the mechanisms and treatment of radiation injury. Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public.