Design of Phase-Changeable and Injectable Alginate Hydrogel for Imaging-Guided Tumor Hyperthermia and Chemotherapy
Design of Phase-Changeable and Injectable Alginate Hydrogel for Imaging-Guided Tumor Hyperthermia and Chemotherapy
复制标题
用于成像引导肿瘤热疗和化疗的相变可注射海藻酸盐水凝胶的设计
DOI：
10.1021/acsami.7b17608
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发表时间：
2018
影响因子：
9.5
通讯作者：
Wang Shige
中科院分区：
文献类型：
--
作者：
Zhao Jiulong;Li Jialing;Zhu Chunping;Hu Fei;Wu Hongyu;Man Xiaohua;Li Zhaoshen;Ye Changqing;Zou Duowu;Wang Shige
本研究的目的是构建一种基于藻酸盐（AG）的相变可注射水凝胶，用于图像引导的肿瘤热疗和化疗。基于AG的α-l-古洛糖醛酸嵌段与钙离子之间的结合，AG/MoS 2/Bi 2S 3-聚（乙二醇）（MBP）/多柔比星（DOX）溶液形成交联水凝胶，以将MBP纳米片和DOX同时包封在水凝胶基质中。原位形成的水凝胶可以作为一个水库，以控制捕获的药物分子的释放，和掺杂的MBP纳米片和DOX可以实现计算机断层扫描/光声双模态成像引导在体内肿瘤光热治疗和化疗，分别。AG/MBP/DOX水凝胶具有优良的光热转换性能，质量消光系数为45.1L/g/cm，光热转换效率为42.7%。此外，MBP的光热转化产生的热量可以促进药物从水凝胶中扩散，从而实现按需药物释放。此外，水凝胶系统可以抑制MBP和DOX在治疗过程中进入血流，从而大大降低它们对正常器官的副作用。更重要的是，AG水凝胶的载药量是一般的，并且可以扩展到抗生素（例如阿莫西林）的包封，用于预防术后感染。
The objective of the present study was to construct an alginate (AG)-based phase-changeable and injectable hydrogel for imaging-guided tumor hyperthermia and chemotherapy. Based on the binding between the α-l-guluronic blocks of AG and calcium ions, the AG/MoS2/Bi2S3-poly(ethylene glycol) (MBP)/doxorubicin (DOX) solution formed a cross-linked hydrogel to simultaneously encapsulate MBP nanosheets and DOX within the hydrogel matrix. The in situ formed hydrogel can act as a reservoir to control the release of entrapped drug molecules, and the doped MBP nanosheets and DOX can realize computed tomography/photoacoustic dual-modal imaging-guided in vivo tumor photothermal therapy and chemotherapy, respectively. The AG/MBP/DOX hydrogel exhibited excellent photothermal conversion properties with mass extinction coefficient of 45.1 L/g/cm and photothermal conversion efficiency of 42.7%. Besides, the heat from the photothermal transformation of MBP can promote drug diffusion from the hydrogel to realize on-demand drug release. Additionally, the hydrogel system can restrain MBP and DOX from entering into the blood stream during therapy, and therefore substantially decrease their side effects on normal organs. More importantly, the drug loading of the AG hydrogel was general and can be extended to the encapsulation of antibiotics, such as amoxicillin, for the prevention of postoperative infections.