INVOLVEMENT OF THE LOCUS COERULEUS IN PICKS DISEASE WITH OR WITHOUT PICK BODY FORMATION
INVOLVEMENT OF THE LOCUS COERULEUS IN PICKS DISEASE WITH OR WITHOUT PICK BODY FORMATION
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DOI：
10.1007/bf00294240
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
AKASHI, T
中科院分区：
文献类型：
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作者：
ARIMA, K;AKASHI, T
根据Pick小体（PB）在大脑皮质中的检出情况（PB阳性组，6例）和阴性组（PB阴性组，8例），将额颞型Pick病患者分为两个亚组，并进行神经病理学检查。对照组包括7例非退行性疾病患者。蓝斑（LC）的神经元群体进行了定量估计，从LC的中间部分的制剂。通过Mann-Whitney U检验对数据进行统计学分析。组织学和超微结构的研究也进行了。获得了以下结果：（1）在发病年龄、死亡年龄、疾病持续时间、死亡时的临床分期和脑重量方面，PB阳性组和PB阴性组之间没有明显差异;（2）LC中的平均神经细胞计数为43.7 ± 0.1。5.2对照组为28.8 ± 0.01。11.7 PB阳性组为42.9 ±。7.6在PB阴性组。PB阳性组神经细胞计数明显低于对照组（P
Brains affected by the fronto-temporal type of Pick''s disease were classified into two subgroups according to whether Pick bodies (PBs) were detectable in cerebral cortex (PB-positive group, six cases) or not (PB-negative group, eight cases), and examined neuropathologically. Controls included seven patients with non-degenerative diseases. The neuronal population in the locus coeruleus (LC) was estimated quantitatively in preparations from the middle part of the LC. The data were analyzed statistically by the Mann-Whitney U-test. Histological and ultrastructural studies were also carried out. The following results were obtained: (1) there were no appreciable differences between the PB-positive and PB-negative groups with regard to age at onset, age at death, duration of illness, clinical stage at death, and brain weight; (2) the mean nerve cell counts in the LC were 43.7 .+-. 5.2 in the controls, 28.8 .+-. 11.7 in the PB-positive group, and 42.9.+-.7.6 in the PB-negaive group. The nerve cell count in the PB-positive group was significantly lower (P