Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort
Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort
复制标题
DOI：
10.1093/ajcn/67.6.1111
复制
发表时间：
1998-06-01
影响因子：
7.1
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Gunnell, DJ;Frankel, SJ;Smith, GD
很少有研究调查儿童超重和成人疾病之间的关系。在一项基于卡内基（Boyd Orr） 1937-1939年英国家庭饮食与健康调查的队列研究的57年随访中，我们研究了儿童和成人全因BMI与心血管死亡率之间的关系。完整的基线和随访数据来自1165名男性和1234名女性，他们在接受检查时的年龄在2岁到14岁9个月之间。全因死亡率和心血管死亡率与较高的儿童bmi有关。与BMI指数在25 - 49百分位数之间的人相比，年龄和性别BMI指数高于75百分位数的人全因死亡率的风险比（95% CI）为1.5(1.1,2.2)，缺血性心脏病的风险比为2.0（1.0,3.9）。这也暗示了与总体死亡率的非线性关联；BMI分布在25-49百分位的人死亡率最低。这种线性关联可能部分归因于童年和成年之间的BMI跟踪。已知成人的高BMI与血压升高和血脂异常有关。成人和儿童超重对观察到的死亡率模式的相对贡献是不确定的。从公共卫生的角度来看，旨在减轻儿童体重的战略是重要的，但只有在这种减肥持续到成年的情况下，才可能影响成人的健康。
Few studies have examined associations between childhood overweight and adult disease. We examined the relation between BMI measured in childhood and adult all-cause and cardiovascular mortality in a 57-y follow-up of a cohort study based on the Carnegie (Boyd Orr) Survey of Family Diet and Health in prewar Britain (1937-1939). Complete baseline and follow-up data were available for 1165 males and 1234 females who were aged between 2 y and 14 y 9 mo when they were examined. All-cause and cardiovascular mortality were associated with higher childhood BMIs. Compared with those with BMIs between the 25th and 49th centiles, the hazard ratio (95% CI) for all-cause mortality in those above the 75th BMI centile for their age and sex was 1.5 (1.1, 2.2) and for ischemic heart disease it was 2.0 (1.0, 3.9). There was also a suggestion of a nonlinear association with overall mortality; those in the 25-49th centile of the BMI distribution had the lowest mortality rates. The linear associations may be due in part to the tracking of BMI between childhood and adulthood. High BMI in adults is known to be associated with raised blood pressure and abnormal lipid profiles. The relative contributions of adult and childhood overweight to the observed mortality patterns are uncertain. From the public health perspective, strategies aimed at reducing weight in childhood are important but may only affect adult health if such weight reduction persists into adulthood.