Glioblastoma genetics: in rapid flux.
Glioblastoma genetics: in rapid flux.
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DOI：
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发表时间：
2010-02
影响因子：
1.4
通讯作者：
B. Purow;D. Schiff
中科院分区：
文献类型：
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作者：
B. Purow;D. Schiff
胶质母细胞瘤是最常见和最致命的原发性脑肿瘤。虽然近年来在治疗这种癌症方面取得了很小的进展，但胶质母细胞瘤在很大程度上仍然对所有现有疗法具有抗药性。人们希望这种癌症遗传学的解剖将导致更有针对性和更有效的治疗，新的进展可能最终使这一目标更接近实现。在过去的几年里，高通量的努力，如癌症基因组图谱和大规模测序项目已经产生了新的见解和这种可怕的癌症的分类。对诊所护理服务的可能影响可能只有几年的时间。胶质母细胞瘤遗传学的快速和令人兴奋的进展步伐促使了这一最新的审查。
Glioblastoma is the most common and most lethal primary brain tumor. While small progress has been made in treating this cancer in recent years, glioblastoma remains largely resistant to all existing therapies. It has been hoped that dissection of the genetics of this cancer would lead to more targeted and effective treatments, and new advances may finally be bringing this closer to fruition. Within the last few years, high-throughput efforts such as The Cancer Genome Atlas and a massive sequencing project have yielded novel insights and classifications of this dreaded cancer. The likely impact on care delivery in the clinic may only be a few years away. The rapid and exciting pace of advances in glioblastoma genetics has prompted this up-to-date review.