Sterile inflammatory responses mediated by the NLRP3 inflammasome.
Sterile inflammatory responses mediated by the NLRP3 inflammasome.
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DOI:
10.1002/eji.200940207
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发表时间:
2010-03
影响因子:
5.4
通讯作者:
Sutterwala, Fayyaz S.
中科院分区:
文献类型:
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作者:
Cassel, Suzanne L.;Sutterwala, Fayyaz S.
Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors (NLR) in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
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影响因子:
4.4
作者:
Li, Hanfen;Willingham, Stephen B.;Ting, Jenny P. -Y.;Re, Fabio
通讯作者:
Re, Fabio
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