Initial equilibration of albumin in rabbit hindpaw skin and lymph.
Initial equilibration of albumin in rabbit hindpaw skin and lymph.
复制标题
兔后爪皮肤和淋巴液中白蛋白的初始平衡。
DOI：
10.1152/ajpheart.1988.254.1.h89
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Bell,DR
中科院分区：
文献类型：
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作者：
Powers,MR;Wallace,JR;Bell,DR
我们比较了麻醉兔后足跟皮中125i标记兔白蛋白在对照条件下、静脉压升高（IVP）和动脉内输注罂粟碱或缓激肽的初始血浆与血管外、血浆与淋巴平衡。实验期间血浆示踪剂浓度保持恒定。示踪剂输注3、5.5和11 h后，对照组淋巴结前淋巴相对于血浆特异性活性（L*/P*）显著高于血管外相对于血浆特异性活性（M/P） （P < 0.01）。罂粟碱使淋巴流量和淋巴白蛋白通量（LCL）增加2.4倍，但未显著改变血管外白蛋白团块（MA）。IVP使LCL升高2.5倍，MA降低25%。3 h时的L*/P*为罂粟碱后对照的2倍。罂粟碱和IVP对3 h M*/P*无显著影响。缓激肽使LCL增加10倍，MA增加2.3倍。L*/P*和M*/P*分别为对照的3.1和4.3倍。这些数据与血管外白蛋白以不同速率分布到两个与血浆平衡的池相一致。罂粟碱和IVP影响快速池，而缓激素影响两个池。
We compared initial plasma to extravascular and plasma to lymph equilibrations of 125I-labeled rabbit albumin in hindpaw heelskin of anesthetized rabbits during control conditions, increased venous pressure (IVP), and intra-arterial infusions of papaverine or bradykinin. Plasma tracer concentrations were maintained constant during the experiments. Control prenodal lymph specific activity relative to plasma specific activity (L*/P*) was significantly greater (P less than 0.01) than extravascular specific activity relative to plasma specific activity (M/P) following 3, 5.5, and 11 h of tracer infusion. Papaverine increased lymph flow and lymph albumin flux (LCL) 2.4-fold, without significantly changing the extravascular albumin mass (MA). IVP increased LCL 2.5-fold and decreased MA 25%. L*/P*at 3 h was twice control following papaverine. M*/P*at 3 h was not significantly affected by papaverine or IVP. Bradykinin increased LCL 10-fold and MA 2.3-fold. L*/P*and M*/P*were 3.1 and 4.3 times control, respectively. The data are consistent with extravascular albumin distributing into two pools that equilibrate with plasma at different rates. Papaverine and IVP affect the faster pool, whereas bradykinin affects both pools.