Genetic control of immunoglobulin isotype restriction.
Genetic control of immunoglobulin isotype restriction.
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免疫球蛋白同种型限制的遗传控制。
DOI：
10.1007/978-3-642-70740-7_30
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发表时间：
1985
影响因子：
--
通讯作者：
Slack,JH
中科院分区：
文献类型：
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作者：
Slack,JH
哺乳动物IG重链类型包括IgM、IgD和IgE类、两种伊加和四种IgG亚类。然而，与大多数免疫功能相关的IG仅限于这些许多同种型中的少数几种。例如，人、大鼠和小鼠的IgG亚类优先被两种抗原刺激（Yount等人，1968; Perlmutter等人，1978; Nahm等人，1980; Slack等人，1980）和有丝分裂原（McKearn等，1982），许多免疫缺陷局限于伊加或IgG亚类，鼠以及人系统性红斑狼疮的高丙种球蛋白血症和许多其它人类免疫疾病如与超敏反应相关的特应性是同种型限制的（Perlmutter等; 1979年，Slack等人，1984; Heiner，1984）。这些在不同物种中保守的同种型限制模式可能表明重要的同种型特异性遗传控制。在这方面，近交系小鼠品系的遗传上相同的个体具有共同的正常血清同种型组成并不令人惊讶，但是不同来源的近交系品系之间的同种型谱可能显著不同（Barth et al.，1965; Natsuume-Sakai等人，1976年）。在本报告中，在两个近交系BALB/c（C）和C57 BL/Ka（B）中证明了不同的脾同种型分泌细胞谱，它们在许多主要免疫应答（IR）基因连锁群中存在差异，包括MHC和IgCH相关的IR基因。对Bailey CX B重组近交系（RI）和相互C和B衍生的IG同源株的脾同种型分泌细胞谱的分析确定了控制同种型偏好模式的连锁群。
Mammalian Ig heavy chain types include the IgM, IgD and IgE classes, two IgA, and four IgG subclasses. Ig associated with most immune functions, however, is limited to only a few of these many isotypes. For example, IgG subclasses of man, rat, and mouse are preferentially stimulated by both antigens (Yount et al., 1968; Perlmutter et al., 1978; Nahm et al., 1980; Slack et al., 1980) and mitogens (McKearn et al., 1982), many immunodeficiencies are limited to IgA or IgG subclasses, hypergammaglobulinemias of murine as well as human systemic lupus erythematosus and many other immune disorders of man such as atopy associated with hypersensitivities are isotype restricted (Perlmutter et al.; 1979, Slack et al., 1984; Heiner, 1984). These isotype restriction patterns which appear conserved in divergent species may be indicative of important isotype specific genetic controls. In this regard, it is not surprising that genetically identical individuals of inbred mouse strains have common normal serum isotype compositions, but isotype profiles among inbred strains of diverse origin can differ dramatically (Barth et al., 1965; Natsuume-Sakai et al., 1976). In this report, distinct splenic isotype secreting cell profiles are demonstrated in two inbred strains BALB/c (C) and C57BL/Ka (B) that vary in a number of major immune response (IR) gene linkage groups including MHC and IgCHassociated IR genes. Analysis of splenic isotype secreting cell profiles of Bailey CXB recombinant inbred (RI) and reciprocal C and B derived Ig congenic strains has determined linkage groups that control isotype preference patterns.