Recruitment of men to a multi-centre diabetes prevention trial: an evaluation of traditional and online promotional strategies
Recruitment of men to a multi-centre diabetes prevention trial: an evaluation of traditional and online promotional strategies
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DOI：
10.1186/s13063-019-3485-2
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发表时间：
2019-06-19
期刊：
影响因子：
2.5
通讯作者：
Wittert, Gary
中科院分区：
文献类型：
--
作者：
Bracken, Karen;Hague, Wendy;Wittert, Gary
背景：需要有效的干预措施来预防目前2型糖尿病患病率的快速增长。预防2型糖尿病的大规模干预措施的临床试验是必不可少的，但招募是具有挑战性和昂贵的，并且关于最具成本效益和最有效的招募方法的数据有限。本文旨在评估用于招募男性参加大型2型糖尿病预防试验的一系列促销策略的成本和有效性。方法在睾酮预防2型糖尿病（T4DM）研究中进行了一项观察性研究，这是一项大型多中心随机对照试验（RCT），研究睾酮治疗对50-74岁糖尿病高危男性2型糖尿病的预防作用。通过电视、报纸、广播等主流媒体宣传参与研究；通过群发邮件、公开张贴海报和参加当地活动进行直接营销；包括Facebook和b谷歌在内的数字平台；以及社区组织和企业的在线推广。对于每个策略，所产生的参与者数量和所涉及的直接成本都被记录下来。每个战略所需的工作人员努力是根据工作人员的反馈估计的。结果在19022名男性中，1007名（5%）入组。最有效的招聘策略是有针对性的广播广告（占参与者的42%），电视新闻报道（20%）和大量邮件（17%）。其他策略，包括广播新闻、公开展示海报、参加当地活动、报纸广告、在线促销以及谷歌和Facebook广告，每种策略占注册参与者的比例都不超过4%。每个随机参与者的招聘促销平均花费为594澳元。最具成本效益的付费策略是由政府卫生机构大规模邮寄（每位参与者745澳元）。其他付费策略更昂贵：全科医生（gp）邮寄（每位参与者1104澳元），广播广告（1081澳元）和报纸广告（1941澳元）。结论广播广告、电视新闻报道和政府卫生机构的大量邮件是最有效的招聘策略。密切监测招聘结果和不断加强招聘活动在该随机对照试验的招聘中发挥了核心作用。试验注册anzctr， ID: ACTRN12612000287831。于2012年3月12日注册。
BackgroundEffective interventions are required to prevent the current rapid increase in the prevalence of Type 2 diabetes. Clinical trials of large-scale interventions to prevent Type 2 diabetes are essential but recruitment is challenging and expensive, and there are limited data regarding the most cost-effective and efficient approaches to recruitment. This paper aims to evaluate the cost and effectiveness of a range of promotional strategies used to recruit men to a large Type 2 diabetes prevention trial.MethodsAn observational study was conducted nested within the Testosterone for the Prevention of Type 2 Diabetes (T4DM) study, a large, multi-centre randomised controlled trial (RCT) of testosterone treatment for the prevention of Type 2 diabetes in men aged 50-74years at high risk of developing diabetes. Study participation was promoted via mainstream mediatelevision, newspaper and radio; direct marketing using mass mail-outs, publicly displayed posters and attendance at local events; digital platforms, including Facebook and Google; and online promotions by community organisations and businesses. For each strategy, the resulting number of participants and the direct cost involved were recorded. The staff effort required for each strategy was estimated based on feedback from staff.ResultsOf 19,022 men screened for the study, 1007 (5%) were enrolled. The most effective recruitment strategies were targeted radio advertising (accounting for 42% of participants), television news coverage (20%) and mass mail-outs (17%). Other strategies, including radio news, publicly displayed posters, attendance at local events, newspaper advertising, online promotions and Google and Facebook advertising, each accounted for no more than 4% of enrolled participants. Recruitment promotions cost an average of AU$594 per randomised participant. The most cost-effective paid strategy was mass mail-outs by a government health agency (AU$745 per participant). Other paid strategies were more expensive: mail-out by general practitioners (GPs) (AU$1104 per participant), radio advertising (AU$1081) and newspaper advertising (AU$1941).ConclusionRadio advertising, television news coverage and mass mail-outs by a government health agency were the most effective recruitment strategies. Close monitoring of recruitment outcomes and ongoing enhancement of recruitment activities played a central role in recruitment to this RCT.Trial registrationANZCTR, ID: ACTRN12612000287831. Registered on 12 March 2012.