AXIS SPECIFICATION IN THE DEVELOPING DROSOPHILA APPENDAGE - THE ROLE OF WINGLESS, DECAPENTAPLEGIC, AND THE HOMEOBOX GENE ARISTALESS
AXIS SPECIFICATION IN THE DEVELOPING DROSOPHILA APPENDAGE - THE ROLE OF WINGLESS, DECAPENTAPLEGIC, AND THE HOMEOBOX GENE ARISTALESS
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DOI：
10.1016/0092-8674(93)90732-6
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发表时间：
1993-09-24
期刊：
影响因子：
64.5
通讯作者：
TOMLINSON, A
中科院分区：
文献类型：
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作者：
CAMPBELL, G;WEAVER, T;TOMLINSON, A
果蝇的无翼(WG)和十足瘫痪(DPP)基因编码分泌生长因子的同源物，是附件正确构型所必需的。我们表明，腿和翅膀的假定尖端，即近端远端轴的远端，其特征是表达WG、DPP和同源盒基因aristess(Al)的细胞密切相关。WG的异位表达既可以诱导异位表达，也可以诱导近端远端轴的重复(多生腿的发育)，但仅在表达高水平DPP的区域。异位表达可以诱导翅膀近端远端轴的复制，这表明它也可能直接参与了轴的指定。近端轴可以通过一种机制来指定，该机制涉及表达WG、DPP和可能的al的细胞之间的直接相互作用。
The wingless (wg) and decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the close association of cells expressing wg, dpp, and the homeobox gene aristaless (al). Ectopic expression of wg can induce both ectopic al expression and a duplication of the proximodistal axis (the development of supernumerary legs), but only in regions expressing high levels of dpp. Ectopic al expression can induce a duplication of the proximodistal axis in the wing, suggesting that it may also be directly involved in axis specification. The proximodistal axis may be specified via a mechanism involving a direct interaction between cells expressing wg, dpp, and possibly al.