Akt signaling in platelets and thrombosis.
Akt signaling in platelets and thrombosis.
复制标题
血小板和血栓形成中的 Akt 信号传导。
DOI：
10.1586/ehm.09.75
复制
发表时间：
2010-02
影响因子：
2.8
通讯作者：
Woulfe DS
中科院分区：
文献类型：
--
作者：
Woulfe DS
Akt is a Ser–Thr kinase with pleiotropic effects on cell survival, growth and metabolism. Recent evidence from gene-deletion studies in mice, and analysis of human platelets treated with Akt inhibitors, suggest that Akt regulates platelet activation, with potential consequences for thrombosis. Akt activation is regulated by the level of phosphoinositide 3-phosphates, and proteins that regulate concentrations of this lipid also regulate Akt activation and platelet function. Although the effectors through which Akt contributes to platelet activation are not definitively known, several candidates are discussed, including endothelial nitric oxide synthase, glycogen synthase kinase 3β, phosphodiesterase 3A and the integrin β3 tail. Selective inhibitors of Akt isoforms or of proteins that contribute to its activation, such as individual PI3K isoforms, may make attractive targets for antithrombotic therapy. This review summarizes the current literature describing Akt activity and its regulation in platelets, including speculation regarding the future of Akt or its regulatory pathways as targets for the development of antithrombotic therapies.
登录
查看更多内容
影响因子：
20.3
作者：
Carmona, Guillaume;Goettig, Stephan;Chavakis, Emmanouil
通讯作者：
Chavakis, Emmanouil
影响因子：
64.8
作者：
Dimmeler, S;Fleming, I;Zeiher, AM
通讯作者：
Zeiher, AM
DOI：
10.1161/01.atv.0000184765.59207.f3
发表时间：
2005-11-01
影响因子：
8.7
作者：
Chakrabarti, S;Varghese, S;Freedman, JE
通讯作者：
Freedman, JE
影响因子：
20.3
作者：
Canobbio, Ilaria;Stefanini, Lucia;Torti, Mauro
通讯作者：
Torti, Mauro
影响因子：
4.8
作者：
Banfic, H;Downes, CP;Rittenhouse, SE
通讯作者：
Rittenhouse, SE